Effect of flavonol glycoside in mulberry (Morus alba L.) leaf on glucose metabolism and oxidative stress in liver in diet-induced obese mice

Journal of the Science of Food and Agriculture
Takuya KatsubeYukikazu Yamasaki

Abstract

Mulberry therapies on type 2 diabetic patients or streptozotocin-induced diabetic rats have been reported to improve fasting blood glucose levels. We investigated the effects of dietary consumption of mulberry-leaf powder and purified quercetin 3-(6-malonylglucoside), the quantitatively major flavonol glycoside in mulberry leaves, on glucose and lipid metabolism in high-fat diet-induced obese mice. Male C57BL/6J mice aged 8 weeks were assigned to three groups (control, mulberry leaf powder (MLP), and quercetin 3-(6-malonylglucoside) (Q3MG)) and treated with their respective diets for 8 weeks. We found that dietary supplementation of 10 g MLP kg(-1) or 1 g Q3MG kg(-1) in high-fat diet effectively suppressed blood glucose levels. We also noted increased expression of glycolysis-related genes and suppression of thiobarbituric acid reactive substances concentrations in the liver of Q3MG group compared to control mice. Dietary consumption of Q3MG, the quantitatively major flavonol glycoside in mulberry leaves, improved hyperglycemia in obese mice and reduced oxidative stress in the liver.

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Citations

Feb 24, 2016·International Journal of Molecular Sciences·Magdalena DziałoAnna Kulma
Oct 9, 2015·Journal of Agricultural and Food Chemistry·Wei YangBaoru Yang
Aug 21, 2015·Journal of Agricultural and Food Chemistry·Hao HeYan-Hua Lu
May 7, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Hyo Geun KimMyung Sook Oh
Jan 13, 2016·Journal of the Science of Food and Agriculture·Mari SugiyamaHiroyuki Itamura
Sep 1, 2016·Journal of Agricultural and Food Chemistry·Mari SugiyamaHiroyuki Itamura
Dec 7, 2018·The American Journal of Chinese Medicine·Helin WeiLin Zhu
Jul 24, 2020·Journal of Food Biochemistry·Yi-Chiao LinJason T C Tzen
Jan 10, 2020·Journal of Agricultural and Food Chemistry·Dong LiNingjia He
Nov 7, 2021·Journal of Animal Physiology and Animal Nutrition·Zhenwu HuangFangxiong Shi
Nov 26, 2021·Journal of Biochemical and Molecular Toxicology·Asha SinghSangeeta Shukla

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