PMID: 2509732Sep 1, 1989Paper

Effect of flunixin meglumine on prostaglandin F2 alpha synthesis and metabolism in the pig

Journal of Veterinary Pharmacology and Therapeutics
K OdensvikH Kindahl

Abstract

The effect of flunixin meglumine on prostaglandin synthesis and metabolism was evaluated in the pig in vivo. It was found that the prostaglandin metabolite, 15-ketodihydro-PGF2 alpha, was decreased in the peripheral circulation within 20 min of injection of the drug. In therapeutic doses in the pig the drug had no effect on the metabolism of PGF2 alpha. Flunixin was compared with some other non-steroidal anti-inflammatory drugs in an in vitro test system utilizing sheep vesicular gland microsomes. It was concluded that this drug is a potent inhibitor of prostaglandin synthesis.

References

Jan 1, 1978·Annual Review of Biochemistry·B SamuelssonC Malmsten
Mar 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Basu
Sep 1, 1987·The British Veterinary Journal·P LeesA D Sedgwick

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Citations

Jun 16, 2005·The Veterinary Clinics of North America. Food Animal Practice·Grant S Frazer
Jun 6, 1998·Animal Reproduction Science·K OdensvikH Kindahl
Aug 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·J M SwinkelsJ H Verheijden
Feb 1, 1990·Zentralblatt für Veterinärmedizin. Reihe A·S AiumlamaiH Kindahl
Oct 1, 1993·Zentralblatt für Veterinärmedizin. Reihe A·K Odensvik, G Fredriksson
Aug 1, 1995·Zentralblatt für Veterinärmedizin. Reihe A·M WallgrenH Rodriguez-Martinez
Nov 27, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·K KönigssonH Kindahl

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