Effect of fluoride on major organs with the different time of exposure in rats

Environmental Health and Preventive Medicine
Thanusha PereraRoshitha Waduge

Abstract

High fluoride levels in drinking water in relation to the prevalence of chronic kidney disease of unknown etiology (CKDu) in Sri Lanka were investigated using rats as an experimental model. The effects of fluoride after oral administration of Sodium fluoride (NaF) at levels of 0, 0.5, 5 and 20 ppm F- were evaluated in adult male Wistar rats. Thirty-six rats were randomly divided into 4 groups (n = 9), namely, control, test I, II, and III. Control group was given daily 1 ml/rat of distilled water and test groups I, II, and III were treated 1 ml/rat of NaF doses of 0.5, 5, and 20 ppm, respectively, by using a stomach tube. Three rats from the control group and each experimental group were sacrificed after 15, 30, and 60 days following treatment. Serological and histopathological investigations were carried out using blood, kidney, and liver. No significant differences were observed in body weight gain and relative organ weights of the liver and kidney in fluoride-treated groups compared to control group. After 60 days of fluoride administration, group I showed a mild portal inflammation with lytic necrosis while multiple areas of focal necrosis and various degrees of portal inflammation were observed in groups II and III. This wa...Continue Reading

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Citations

Apr 6, 2019·Environmental Science and Pollution Research International·Jiping GaoGuohua Song
Sep 1, 2020·Biological Trace Element Research·Yugandhar P ReddyVarun Kumar Sharma
Jul 15, 2020·Human & Experimental Toxicology·A M EmaraR M Elgarabawy
Dec 11, 2020·Chemosphere·Jelena RadovanovićZoran Mandinić
Sep 13, 2019·Ecotoxicology and Environmental Safety·Ling LiuAiguo Wang
Oct 2, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Raghavendra MittaAbbulu Konde
Feb 26, 2021·Biological Trace Element Research·Haojie LiJinming Wang
Mar 17, 2021·Chemical Reviews·Jianlin HanVadim A Soloshonok
Jun 22, 2021·Journal of Water and Health·Sachithra Imbulana, Kumiko Oguma

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