Effect of fluoroquinolones on plasma glucose levels in fasted and glucose-loaded mice

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Seiji HoriMasahiro Kawamura

Abstract

In fasted mice, plasma glucose levels were reduced by intraperitoneal administration of enoxacin, lomefloxacin, or gatifloxacin (50 mg/kg). A lower dose of these fluoroquinolones (5 mg/kg) also reduced the plasma glucose (PG) levels in glucose-loaded mice. Ciprofloxacin and levofloxacin did not reduce these levels in either fasted or glucose-loaded mice. These results suggest that each fluoroquinolone has an individual hypoglycemic action, and fluoroquinolone administration after meals might reduce PG levels at lower doses.

References

Jan 1, 1996·British Journal of Pharmacology·N MaedaA Iguchi
Aug 24, 2004·European Journal of Pharmacology·Atsunori SarayaSusumu Seino

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Citations

Feb 26, 2008·Pharmacy World & Science : PWS·Ahunna J OnyenwenyiRandy C Hatton
Aug 30, 2012·Health Physics·P Artur PlettChristie M Orschell
Jun 2, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Seiji Hori
Oct 4, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Seiji Hori
Jan 14, 2010·The Journal of Veterinary Medical Science·Mikiko NagaiKazuhisa Furuhama
Apr 20, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Hans H Liu
May 25, 2012·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Mais AbsiUrs T Ruegg

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