Effect of Fluosol on oxygen availability, regional cerebral blood flow, and infarct size in a model of temporary focal cerebral ischemia

Stroke; a Journal of Cerebral Circulation
S KolluriN Zervas

Abstract

Twenty-four cats had an intravenous infusion of either Fluosol or saline and then were subjected to 2 hours of middle cerebral artery occlusion. All the animals infused with Fluosol and one-half the animals infused with saline were ventilated with 100% O2. Tissue oxygen availability and regional cerebral blood flow were measured by platinum electrodes using direct voltage recordings for oxygen measurements and hydrogen clearance curves for measurements of cerebral blood flow. With 100% oxygenation tissue oxygen availability increased significantly in the Fluosol treated animals, however, during the time of ischemia oxygen availability decreased below baseline values to about an equal level whether the animals were treated with Fluosol or saline. Regional cerebral blood flow fell to a similar value in all groups during the time of occlusion. One hour after reperfusion blood flow increased considerably above baseline values in all groups and oxygen availability also increased in all groups but particularly in the Fluosol treated animals. Overall mortality and the size of infarction 1 week after the ischemic insult were not significantly different in the three groups. Mortality was directly related to the size of the infarct which...Continue Reading

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Citations

Jan 1, 1988·Acta Neuropathologica·S KolluriN Zervas
Dec 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·B S AspeyM J Harrison
Aug 1, 1996·Journal of Neurosurgery·D E SakasN T Zervas
May 1, 1994·Stroke; a Journal of Cerebral Circulation·G M de Courten-Myers, R E Myers
May 1, 1994·Stroke; a Journal of Cerebral Circulation·A ArboixF Titus
Mar 1, 1989·Stroke; a Journal of Cerebral Circulation·R C Heros, K Korosue
Mar 1, 1995·Perfusion·A Marchbank
Oct 1, 1992·Stroke; a Journal of Cerebral Circulation·K Korosue, R C Heros

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