Effect of fluoxetine on induced tooth movement in rats

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
Giovana Carla Franzon FrigottoElisa Souza Camargoa

Abstract

Fluoxetine is a widely used antidepressant. Its various effects on bone mineral density are well described. The aim of this study was to evaluate the effect of fluoxetine on induced tooth movement. Seventy-two Wistar rats were divided into 3 groups: M (n = 24; 0.9% saline solution and induced tooth movement), FM (n = 24; fluoxetine, 10 mg/kg, and induced tooth movement), and F (n = 24; fluoxetine, 10 mg/kg only). After 30 days of daily saline solution or fluoxetine administration, an orthodontic appliance (30 cN) was used to displace the first molar mesially in groups M and FM. The animals were killed 3, 7, and 14 days after placement of the orthodontic appliances. The animals in group F did not receive induced tooth movement but were killed at the same times. We evaluated tooth movement rates, collagen neoformation rates by polarization microscopy, numbers of osteoclast by tartrate-resistant acid phosphatase, and trabecular bone modeling by microcomputed tomography of the femur. The tooth movement rates were similar in groups M and FM at all studied time points (P >0.05). The rate of newly formed collagen had a reverse pattern in groups M and FM, but the difference was not statistically significant (P >0.05). There were signif...Continue Reading

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Citations

Nov 2, 2016·The Angle Orthodontist·Ana Paula Lazzari Marques PeronElisa Souza Camargo
Dec 17, 2016·Brazilian Dental Journal·Marcel Durante BrunetOdilon Guariza
Mar 10, 2018·European Journal of Orthodontics·Miltiadis A MakrygiannakisAthanasios E Athanasiou
Aug 4, 2016·PloS One·Viviane da Silva KagyAline Cristina Batista Rodrigues Johann
May 6, 2019·Journal of Orthodontics·Miltiadis A MakrygiannakisAthanasios E Athanasiou
Oct 18, 2018·Brazilian Oral Research·Cristiano Miranda de AraujoElisa Souza Camargo
Jan 4, 2021·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Ariane Ximenes Graciano ParraElisa Souza Camargo
Jan 8, 2021·Journal of Dental Research, Dental Clinics, Dental Prospects·Mohammad Sadegh Ahmad AkhoundiAmir Hossein Mirhashemi

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