Effect of fluoxetine on three-year recurrence in acute ischemic stroke: A randomized controlled clinical study

Clinical Neurology and Neurosurgery
Yi-Tao HeYi Guo

Abstract

To evaluate the effect of fluoxetine on three-year recurrence rate of acute ischemic stroke. 404 enrolled patients with acute ischemic stroke were randomly divided into control and treatment groups, and underwent conventional secondary preventive therapy for ischemic stroke. In addition, the treatment group was administered fluoxetine (20 mg daily for 90 days). A three-year follow-up was performed, and indicators related to risk factors of stroke were assessed at day 90 of follow-up. The effect of fluoxetine on the three-year recurrence rate of acute ischemic stroke was evaluated by survival analysis, as well as multifactor Cox regression analysis. The values of systolic blood pressure, blood total cholesterol, blood low density lipoprotein and glycosylated hemoglobin at day 90 of follow-up were significantly lower in treatment group than control group (P = 0.002, P = 0.002, P = 0.018, P = 0.011, respectively). The occurrence rates of epilepsy, gastrointestinal bleeding, syncope, allergic reactions, hemorrhagic infarction, and death were not significantly different between the two groups during the follow-up (P > 0.05). The recurrence-free survival rate of ischemic stroke was significantly lower in the treatment group than cont...Continue Reading

Citations

Apr 27, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Jintao Wang, Daniel T Eitzman
Nov 27, 2019·The Cochrane Database of Systematic Reviews·Lynn A LeggGillian E Mead
Oct 18, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Gillian E MeadGraeme J Hankey
May 27, 2020·Health Technology Assessment : HTA·Martin DennisGillian Mead
May 7, 2021·Medicinal Research Reviews·Qing-Zhang TuoPeng Lei
Aug 7, 2021·Neuropsychiatric Disease and Treatment·Fang LiuKangbai Huang
Sep 28, 2021·Expert Opinion on Drug Safety·Janne Kaergaard Mortensen, Grethe Andersen
Nov 16, 2021·The Cochrane Database of Systematic Reviews·Lynn A LeggGillian E Mead

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