PMID: 9641928Jun 26, 1998Paper

Effect of flutamide on survival in patients with pancreatic cancer: results of a prospective, randomised, double blind, placebo controlled trial

BMJ : British Medical Journal
B Greenway

Abstract

To assess whether flutamide (Drogenil), a pure androgen receptor blocking agent, improves survival in patients with pancreatic carcinoma and thus whether testosterone is a major growth factor for this tumour. A prospective, randomised, double blind placebo controlled trial. 49 patients with a clinical diagnosis of pancreatic carcinoma. 24 patients received flutamide and 25 received placebo. Death of the patient. Analysis of all patients at 6 months and 1 year showed 14 and eight patients alive, respectively, in the flutamide group compared with 10 and one in the placebo group. After exclusion of those patients in both groups who received less than 6 weeks' treatment because of advanced disease and early death the comparable results were 14 (88%) and eight (50%) alive in the flutamide group compared with 10 (50%) and one (5%) in the placebo group. Median survival for all patients was 8 months in the flutamide group compared with 4 months in the placebo group. With the 6 week exclusions median survival was 12 months compared with 5 months, respectively. This study supports the concept that testosterone is a growth factor for pancreatic carcinoma and that blockade of androgen receptors offers an appropriate new approach to treatment.

References

Jan 1, 1989·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·D González-BarcenaA V Schally
Jan 1, 1988·Gastrointestinal Endoscopy·A R KaufmanD R Ferguson
Jun 1, 1987·The British Journal of Surgery·B A Greenway
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T W Redding, A V Schally
Jan 8, 1983·British Medical Journal·B GreenwayR Williams
Sep 19, 1981·British Medical Journal·B GreenwayR Williams
Oct 1, 1982·The British Journal of Surgery·B GreenwayR Williams
Feb 15, 1997·Lancet·S Rosewicz, B Wiedenmann

❮ Previous
Next ❯

Citations

Sep 1, 2005·Investigational New Drugs·Sanjay Singh NegiAdarsh Chaudhary
Mar 13, 1999·BMJ : British Medical Journal·S J WigmoreO J Garden
Sep 15, 2001·BMJ : British Medical Journal·R Smith
May 29, 2000·Postgraduate Medical Journal·A L ThomasW P Steward
Mar 10, 2001·Quality in Health Care : QHC·A MelvilleA Eastwood
Jun 15, 2007·The Journal of Surgical Research·Srivani KonduriRoderich E Schwarz
Jan 14, 2017·Cancers·Michael T Schweizer, Evan Y Yu
Mar 29, 2003·Expert Opinion on Biological Therapy·Lawrence Rosenberg, Mark Lipsett
Oct 29, 2002·British Journal of Cancer·M SuzuokiH Katoh
Sep 13, 2019·Scientific Reports·Dinesh KadariyaRehan Qayyum
Dec 21, 2018·Medicinal Research Reviews·Dan LiTingjun Hou
Feb 24, 2001·The Annals of Pharmacotherapy·M SchulzH Becker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.