PMID: 8600133Sep 1, 1995Paper

Effect of focal cochlear vascular lesion on endocochlear potential in guinea pigs

Hearing Research
B Hu, S Jiang

Abstract

The alteration endocochlear potential (EP) in response to total cochlear ischemia induced by various experimental manipulations has been studied. However, the effect of restricted areal damage to the microvessels (restricted to small area in the lateral wall of a cochlear turn) on the EP value is still unknown. In the current investigation we adopted a photochemical method to produce a focal (i.e., restricted area) microvessel injury in the lateral wall of the guinea pig cochlea and examined the effect of these insults on EP recorded in the same region. The small area of the microvessel lesion (small fenestra: approximately 0.2 x 0.4 mm2) induced by photoactivation did not yield significant EP changes, suggesting that damage to such a small area of microcirculation in the lateral wall of the cochlea has no statistically significant effects on EP values. In subjects with a large area of the microvessel lesion (large fenestra: approximately 0.2 x 0.8 mm2), a decrease in the EP value (mean +/- SEM 7.9 +/- 0.8 mV) was noted. However, the control group animals with a large fenestra but without microvessel lesion also displayed a decrease (8.6 +/- 0.8 mV) in EP. In the current study we were unable to differentiate whether the EP chan...Continue Reading

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Citations

Oct 7, 2004·Hearing Research·Keiji TakemuraToshio Yamashita

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