Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine

Nutrients
Daniel RajdlVaclav Babuska

Abstract

Moderate regular consumption of alcoholic beverages is believed to protect against atherosclerosis but can also increase homocysteine or dimethylglycine, which are putative risk factors for atherosclerosis. We aimed (1) to investigate the effect of alcohol consumption on vitamins and several metabolites involved in one-carbon metabolism; and (2) to find the most effective way of decreasing homocysteine during moderate alcohol consumption. Male volunteers (n = 117) were randomly divided into five groups: the wine-only group (control, 375 mL of white wine daily for one month) and four groups combining wine consumption with one of the supplemented substances (folic acid, betaine, and vitamins B12 or B₆). Significant lowering of homocysteine concentration after the drinking period was found in subjects with concurrent folate and betaine supplementation. Vitamin B12 and vitamin B₆ supplementation did not lead to a statistically significant change in homocysteine. According to a multiple linear regression model, the homocysteine change in the wine-only group was mainly determined by the interaction between the higher baseline homocysteine concentration and the change in dimethylglycine levels. Folate and betaine can attenuate possibl...Continue Reading

References

Jan 1, 2000·Medical Hypotheses·M H Mar, S H Zeisel
Aug 24, 2000·The American Journal of Cardiology·S GorinsteinS Trakhtenberg
Oct 26, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN Homocysteine Studies Collaboration
May 13, 2004·European Journal of Clinical Nutrition·E M LauferP R Taylor
Apr 22, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Romana FemiaEle Ferrannini
Aug 31, 2007·World Journal of Gastroenterology : WJG·Giovanni Tarantino
Nov 1, 2007·American Journal of Epidemiology·Kenneth J MukamalDavid S Siscovick
Nov 6, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ichiro Wakabayashi
Feb 26, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Dimitris TousoulisChristodoulos Stefanadis
May 6, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Winston DunnJeffrey B Schwimmer
Feb 21, 2009·BMC Cardiovascular Disorders·Keiko SuzukiShunichi Homma
Aug 22, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·E PerissinottoUNKNOWN ILSA Working Group
Sep 1, 2009·Future Cardiology·Augusto Di CastelnuovoLicia Iacoviello
Sep 16, 2009·Free Radical Biology & Medicine·Jane A Leopold, Joseph Loscalzo
Oct 14, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manal F AbdelmalekKeith D Lindor
Dec 17, 2009·Genes & Nutrition·Raj LakshmanSamir Zakhari
Jan 20, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Andreia OliveiraCarla Lopes
Apr 13, 2010·Atherosclerosis·Diego Geroldi, Enzo Emanuele
Dec 1, 2010·Internal and Emergency Medicine·Maurizio Ponz de Leon
Nov 15, 2011·European Journal of Epidemiology·Simona CostanzoGiovanni de Gaetano
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalDaniel Simancas-Racines
May 7, 2013·The Medical Journal of Australia·Peter L Thompson
Jun 1, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Gard Frodahl Tveitevåg SvingenOttar Nygård
Sep 17, 2013·Alcoholism, Clinical and Experimental Research·Andrew D PlunkRichard A Grucza
Feb 28, 2014·Cardiovascular Therapeutics·Balazs Debreceni, Laszlo Debreceni

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Citations

Feb 11, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Blanca Escudero-LópezMaría-Soledad Fernández-Pachón
Dec 13, 2019·Cancer Causes & Control : CCC·Joanne F DorganLinda Van Horn
Dec 17, 2016·Journal of Cellular Biochemistry·Avisek MajumderSuresh C Tyagi
Jun 21, 2020·International Journal of Environmental Research and Public Health·Rachel LamAnna Nolan
Mar 26, 2021·Critical Reviews in Food Science and Nutrition·Damoon Ashtary-LarkyAlexei Wong
Sep 4, 2021·Critical Reviews in Food Science and Nutrition·Omid AsbaghiAmirmansour Alavi Naeini
Nov 9, 2021·The British Journal of Nutrition·Damoon Ashtary-LarkyAlexei Wong
Nov 25, 2021·European Journal of Nutrition·Aisha Rehman, Kosha J Mehta

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Methods Mentioned

BETA
High Performance Liquid Chromatography
biopsy

Software Mentioned

R Development Core Team
MedCalc
R

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