Effect of food intake and co-administration of placebo self-nanoemulsifying drug delivery systems on the absorption of cinnarizine in healthy human volunteers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Martin Lau ChristiansenAnette Müllertz

Abstract

Positive food effects may be observed for low aqueous soluble compounds, these effects could potentially be circumvented using lipid based formulations. However, as all compounds are not chemically stable in lipid based systems, alternative dosage regimes could be investigated to evade the stability issue. The two aims for this present study were therefore; i) to investigate if a nutritional drink, Fresubin Energy®, could induce food effect in humans for the poorly soluble compound cinnarizine; and ii) to investigate if co-administration of a self-nano-emulsifying drug delivery systems (SNEDDS) with a conventional cinnarizine tablet could reduce the observed food-effect. A commercial conventional cinnarizine tablet was dosed to 10 healthy volunteers in a cross-over design in both fasted and fed state, with and without co-administration of a SNEDDS, with a one week wash-out period between dosing. The fed state was induced using a nutritional drink (Fresubin Energy®) and gastric emptying was assessed by administration of paracetamol as a marker. The pharmacokinetic analysis showed that the nutritional drink delayed the uptake and increased the fraction of absorbed cinnarizine, indicative of a food effect on the compound. This was...Continue Reading

References

Dec 1, 1975·British Journal of Clinical Pharmacology·W S NimmoL F Prescott
Apr 1, 1977·Journal of Pharmaceutical Sciences·P G WellingP O Madsen
Jun 1, 1988·The Tohoku Journal of Experimental Medicine·F KoizumiM Satoh
Jan 1, 1986·British Journal of Clinical Pharmacology·B N Singh
Sep 1, 1980·The Journal of Laryngology and Otology·G Towse
Apr 1, 1995·British Journal of Clinical Pharmacology·D A AdkinI R Wilding
Jul 5, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A W MedhusE Husebye
Feb 1, 1965·Journal of Pharmaceutical Sciences·G LEVY, W J JUSKO
May 15, 2004·The Journal of Pharmacy and Pharmacology·Sandra KleinJennifer B Dressman
Mar 27, 2007·Pharmaceutical Research·Chong-Hui GuRonald L Smith
Jul 28, 2007·Pharmaceutical Research·Greg A KossenaChristopher J H Porter
Jan 8, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jong Soo WooChong-Kook Kim
Feb 19, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Bena-Marie LueAnette Müllertz
Feb 26, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Flemming Seier NielsenAnette Müllertz
Nov 13, 2008·Pharmaceutical Research·Dimitrios G FatourosAnette Müllertz
Jan 22, 2010·Pharmaceutical Development and Technology·Pawan J KaduSurendra G Gattani
Sep 24, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Philip Carsten ChristophersenAnette Müllertz
Nov 19, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Martin Lau ChristiansenAnette Müllertz

❮ Previous
Next ❯

Citations

Apr 20, 2016·Advanced Drug Delivery Reviews·Orlagh M FeeneyChristopher J H Porter
Sep 30, 2016·Drug Delivery·Bappaditya ChatterjeePinaki Sengupta
Jul 28, 2016·International Journal of Pharmaceutics·Anna-Karin Granath, Kalle Sigfridsson
Jun 30, 2018·The Journal of Pharmacy and Pharmacology·Joseph P O'SheaBrendan T Griffin
Jun 12, 2020·Pharmaceutical Research·Niklas J KoehlBrendan T Griffin
Oct 31, 2020·Drug Development and Industrial Pharmacy·Alexandra-Roxana IlieRené Holm
Mar 2, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Harriet Bennett-LenaneBrendan T Griffin
Feb 22, 2021·Advanced Drug Delivery Reviews·Zahari VinarovPatrick Augustijns
Jun 30, 2021·Biotechnology Advances·Areen AshkarMaya Davidovich-Pinhas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Martin Lau ChristiansenAnette Müllertz
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Philip Carsten ChristophersenAnette Müllertz
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Rene HolmAnette Müllertz
© 2022 Meta ULC. All rights reserved