PMID: 6986535Feb 1, 1980Paper

Effect of food intake on intestinal absorption and mucosal hydrolases in alloxan diabetic rats

Metabolism: Clinical and Experimental
Y NakabouH Hagihira

Abstract

The relation between food intake and enzyme activity of the small intestine and rate of intestinal absorption were studied in rats 15 days after induction of alloxan diabetes. Diabetic rats were given an ad lib. semisynthetic diet or a restricted diet on the basis of either daily intake or body weight. The rates of absorption of 5 mMD-galactose and L-valine were determined in vitro by the everted sac method. The rates of absorption of the substances, expressed per unit weight or per length of intestine, were higher in diabetic rats than in controls, regardless of the amount of food consumed. Maltase and sucrase activities were significantly increased in diabetic rats, regardless of the amount of food consumed. The activity of intestinal alkaline phosphatase was increased in diabetic rats fed ad lib., but not in those on a restricted diet. These findings suggest that in alloxan diabetic rats the increased disaccharidase activity in the small intestine is due to insulin deficiency, and that the increased activity of alkaline phosphatase is only a secondary effect of insulin deficiency, caused by increased food intake resulting from insulin deficiency.

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Citations

Jan 1, 1990·The International Journal of Biochemistry·J M Argiles, F J Lopez-Soriano
Jan 1, 1982·Comparative Biochemistry and Physiology. A, Comparative Physiology·P Pothier, J S Hugon
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Jan 1, 1992·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M Williams, T M Mayhew
Dec 31, 1991·Biochemical and Biophysical Research Communications·K MiyamotoH Hagihira
Jan 16, 2014·American Journal of Physiology. Endocrinology and Metabolism·Thi Thu Huong DoMarion Buyse
Feb 1, 1985·Gastroenterologia Japonica·T TakeguchiM Akagi

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