Effect of food restriction on cold adaptability of rats

Canadian Journal of Physiology and Pharmacology
A Kuroshima, T Yahata

Abstract

To determine the role of the nutritional state in nonshivering thermogenesis during cold adaptation, cold adaptability was compared between cold-adapted (5 degrees C for 4-5 weeks) rats fed ad libitum and cold-adapted rats pair fed with warm controls having the same food intake. Cold-adapted pair-fed rats suffered a significant loss in body weight during cold exposure. However, brown adipose tissue (BAT) in both cold-adapted ad libitum fed and cold-adapted pair-fed rats was enlarged to the same extent as compared with that in control rats. Fat-free dry matter in BAT also increased in cold-adapted ad libitum fed and cold-adapted pair-fed rats to the same extent. Cold tolerance as assessed by the change in the colonic temperature at -5 degrees C was improved relative to control rats and was the same for cold-adapted ad libitum fed and cold-adapted pair-fed rats. Nonshivering thermogenesis as estimated by the noradrenaline-induced increase in oxygen consumption was significantly greater in the cold-exposed rats and there was no significant difference between cold-adapted ad libitum fed and cold-adapted pair-fed rats. These results suggest that an improved cold tolerance by means of nonshivering thermogenesis in brown adipose tissu...Continue Reading

Citations

Aug 1, 1990·Pflügers Archiv : European journal of physiology·M L PuertaA Fernández
Mar 1, 1990·Pflügers Archiv : European journal of physiology·M P NavaM L Puerta
Jan 1, 1987·Comparative Biochemistry and Physiology. A, Comparative Physiology·M L Puerta, M Abelenda
Mar 1, 1997·The American Journal of Physiology·C DuchampM J Dauncey
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Jan 1, 1989·Progress in Lipid Research·J Himms-Hagen

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