PMID: 11929495Apr 4, 2002Paper

Effect of formaldehyde on the expression of adhesion molecules in nasal microvascular endothelial cells: the role of formaldehyde in the pathogenesis of sick building syndrome

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
W J KimA Konno

Abstract

Formaldehyde is associated with sick building syndrome (SBS), a set of diffuse and irritative symptoms predominantly involving the eyes and the respiratory tract. However, its pathophysiological mechanism in SBS has not yet been clarified. In this study we investigated the effect of formaldehyde on the expression of adhesion molecules on human mucosal microvascular endothelial cells (HMMECs). Furthermore, we investigated the effect of formaldehyde on adhesiveness of HMMECs to eosinophils. HMMECs were incubated with various concentrations of formaldehyde (1 ng/mL-1 microg/mL) for 24 h, and the expressions of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1) on HMMECs were evaluated by flow cytometry. The change in the expression of ICAM-1 and VCAM-1 mRNA was then evaluated by reverse transcriptase polymerase chain reaction. To understand the role of formaldehyde in eosinophilic inflammation of the nasal mucosa, we examined the effects of formaldehyde on the adhesiveness between HMMECs and eosinophils by eosinophil adhesion assay. Formaldehyde increased the surface expressions of ICAM-1 and VCAM-1 on HMMECs. Formaldehyde also induced ICAM-1 and VCAM-1 mRNA. In addition, the adhesiveness betwe...Continue Reading

References

May 1, 1992·The Journal of Cell Biology·A G ArroyoF Sánchez-Madrid
Dec 15, 1991·Journal of Immunological Methods·T T HanselC Walker
Jul 1, 1990·Archives of Environmental Health·J D ThrasherR Madison
Dec 1, 1987·Scandinavian Journal of Work, Environment & Health·M K HansenK H Cohr
Dec 1, 1985·The Journal of Allergy and Clinical Immunology·H R Imbus
May 1, 1995·International Archives of Allergy and Immunology·G W CanonicaM Bagnasco
Sep 1, 1994·The Journal of Allergy and Clinical Immunology·B S Bochner, R P Schleimer
Jan 1, 1993·International Archives of Occupational and Environmental Health·K PazdrakU Ruta
Jun 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J HiltonI Kimber
Apr 5, 1997·Lancet·C A RedlichM R Cullen
Apr 1, 1997·The Journal of Allergy and Clinical Immunology·L HåkanssonP Venge
May 1, 1997·Archives of Environmental Health·C S LiM L Tai
Nov 18, 1997·International Archives of Allergy and Immunology·K SaneyoshiH Fujimaki
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J DearmanI Kimber
Mar 27, 1999·Archives of Environmental Health·A Hempel-JørgensenH K Hudnell
Oct 27, 1999·The Science of the Total Environment·F PalmgrenO Hertel
Dec 11, 1999·International Archives of Occupational and Environmental Health·G WieslanderP Venge
Mar 8, 2000·The European Respiratory Journal·S Z WangK D Forsyth

❮ Previous
Next ❯

Citations

Feb 8, 2007·Archives of Toxicology·Donggeun SulWoon-Won Jung
Aug 27, 2004·The Tohoku Journal of Experimental Medicine·Hiroyuki KayabaJunichi Chihara
Apr 4, 2013·Sensors·Po-Ren ChungChia-Yen Lee
Nov 11, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·R Yavuz AricanNurettin Oguz
Apr 16, 2014·Environmental Toxicology·Fan WangYihe Jin
Apr 5, 2005·The Journal of Veterinary Medical Science·Dwi Kesuma SariFumihiko Sasaki
Oct 3, 2014·International Archives of Occupational and Environmental Health·Bo GlasAnna-Lena Sunesson
May 20, 2011·Allergology International : Official Journal of the Japanese Society of Allergology·Minako HisamitsuChisato Mori
May 19, 2006·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Wei-Hsi ChenJia-Shou Liu
Apr 3, 2015·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Andrew Coskey, Thomas R Gest
Jan 1, 2009·Sensors·Jonas FlueckigerKaren C Cheung
Jan 24, 2015·Environmental Health Perspectives·Karen VrijensTim S Nawrot
May 6, 2005·Glycobiology·Masami SuzukiMinoru Fukuda
May 30, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Esther Resines-UrienJosé Sánchez Costa
Sep 1, 2008·Toxicological Research·Guang-Yong LiByung-Hoon Lee
Jan 8, 2021·Biomedical Optics Express·Mateusz Winkowski, Tadeusz Stacewicz
Jan 28, 2004·Otolaryngologic Clinics of North America·Stephen J Chadwick

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2022 Meta ULC. All rights reserved