PMID: 7932225Jun 1, 1994Paper

Effect of formate and oxalate on fluid reabsorption from the proximal convoluted tubule of the anaesthetized rat

The Journal of Physiology
M Wareing, R Green

Abstract

1. It has recently been suggested that both formate and oxalate may be involved in the reabsorption of chloride from the proximal convoluted tubule (PCT). Reabsorption is achieved via a mechanism coupling Na(+)-H+ exchange to Cl(-)-anion exchange thus facilitating net NaCl transport. This possible mechanism was investigated further by observing the effect of luminal addition of formate and oxalate on proximal tubule transport in anaesthetized rats, previously prepared for in vivo microperfusion. 2. Addition of formate (0.25 mmol l-1) to the luminal perfusate resulted in a significant stimulation of fluid reabsorptive rate. 3. Oxalate was found to have a concentration-dependent effect on fluid reabsorption. Luminal oxalate concentrations below 0.05 mmol l-1 stimulated fluid reabsorption, while an oxalate concentration of 0.5 mmol l-1 inhibited fluid reabsorption. 4. The presence of formate (0.25 mmol l-1) and oxalate (0.001 mmol l-1) in the same luminal perfusate stimulated fluid reabsorption from the proximal tubule lumen, but the effects of formate and oxalate were not additive. 5. The removal of bicarbonate from the luminal perfusate and its replacement with phosphate had no significant effect on fluid reabsorptive rate. An a...Continue Reading

Citations

Jan 1, 1997·World Journal of Urology·C F VerkoelenJ C Romijn
Jan 1, 1996·Urological Research·C F Verkoelen, J C Romijn
Feb 16, 2006·Urological Research·Susan Ruth MarengoGregory T MacLennan
Jun 28, 1996·The Journal of Biological Chemistry·S M Kuo, P S Aronson
Jul 18, 2002·The Journal of Biological Chemistry·Zhirong JiangPeter S Aronson
Nov 15, 2018·American Journal of Physiology. Renal Physiology·Felix KnaufPeter S Aronson
Apr 10, 2015·Journal of the American Society of Nephrology : JASN·Nancy S KriegerDavid A Bushinsky
Jul 18, 2001·American Journal of Physiology. Renal Physiology·T WangP S Aronson
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Lawrence P KarniskiPeter S Aronson
Dec 5, 1998·The American Journal of Physiology·T WangG Giebisch
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·F KnaufP S Aronson

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