Effect of formulation and process variables on lipid based sustained release tablets via continuous twin screw granulation: A comparative study

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Venkata Raman KallakuntaMichael A Repka

Abstract

The current study's aim is to prepare lipid based sustained release tablets via a twin-screw granulation technique and compare those dosage forms with conventional techniques, namely wet granulation and direct compression. The granules were successfully manufactured in a single-step, continuous twin-screw granulation process with a low proportion of binder (Klucel™ EF, HPC SSL) using Compritol® 888 ATO, Precirol® ATO 5 and Geleol™ as sustained release agents. The granules prepared showed good flow characteristics and compaction properties. DSC and XRD studies were conducted to characterize the granules prepared via a twin-screw granulation method and the results demonstrated the crystalline nature of lipids within the granules. FTIR data indicated that there were no interactions with the formulation components investigated. The formulations developed by all three methods were compressed into tablets with a mechanical strength of 14-16 KP. The tablets formulated were characterized for physicochemical properties, in vitro drug release studies, water uptake and erosion studies. These results showed that the drug was not completely released after 24 h for tablets developed by the wet granulation process using all three lipids. The ...Continue Reading

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Citations

Apr 23, 2019·Expert Opinion on Drug Delivery·Venkata Raman KallakuntaMichael A Repka
Feb 12, 2021·Advanced Drug Delivery Reviews·Suresh BandariMichael A Repka
Jun 3, 2021·Pharmaceutics·Seth P ForsterTiffany Chiang

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