Effect of four crystalloid cardioplegias on immature rabbit hearts during global ischaemia

Asian Journal of Surgery
Yunqing MeiDayi Hu

Abstract

Controversy surrounds the reported beneficial effects of crystalloid cardioplegic solutions in the immature myocardium. In the present study, we investigated the efficacy of four clinical cardioplegic solutions in the immature myocardium to determine if cardioplegic protection could be demonstrated and, if yes, the relative efficacy of the four solutions. Isolated, working hearts (n=6 per group) from neonatal rabbits (age, 7-14 days) were perfused aerobically (37 C) for 15 minutes in the Langendorff mode and 30 minutes in the working mode before a 2-minute infusion of one of four cardioplegic solutions: the modified St. Thomas' Hospital no. 1 cardioplegic solution, Tyers solution, Bretschneider solution or Roe solution. Hearts were then rendered globally ischaemic for 120 minutes at 14C before reperfusion for 15 minutes in the Langendorff mode and 30 minutes in the working mode. The post-ischaemic recovery of cardiac function and leakage of myocardial enzymes (GOT, CK, CK-MB, LDH, LDH1) were compared with results in non-cardioplegic control hearts. Good protection was observed with modified St. Thomas' Hospital and Tyers solutions: postischaemic recovery of cardiac output was increased from 80.43+/-3.62% in the non-cardioplegic...Continue Reading

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Citations

Aug 5, 2011·Canadian Journal of Physiology and Pharmacology·A E ConsoliniP Bonazzola
Feb 3, 2016·Interactive Cardiovascular and Thoracic Surgery·Branko MimicMiroslav Djordjevic
Dec 18, 2008·Canadian Journal of Physiology and Pharmacology·Alicia E Consolini, Patricia Bonazzola

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