PMID: 7363445Jan 1, 1980

Effect of FPL57787 in exercise-induced asthma

Clinical Allergy
N C ThomsonJ W Kerr

Abstract

In ten patients with extrinsic asthma the effects of a new oral chromone FPL57787 and placebo were studied in a random double-blind fashion to assess the effect of FPL57787 in preventing exercise-induced asthma (EIA). Exercise testing consisted of steady state running on an inclined treadmill for up to 8 min. FPL57787 gave significant protection (P less 0.01) compared to placebo from the maximum percentage fall in FEV1, FVC and MMEF after exercise. FPL57787 also produced a small but significant (P less than 0.01) percentage increase in FEV1 2 hr after the drug compared to placebo, whereas no significant increase was seen in FVC or in MMEF.

References

Jul 1, 1975·The Journal of Allergy and Clinical Immunology·S Godfrey
Oct 1, 1977·Agents and Actions·J AugsteinP Sheard
Jul 1, 1972·The American Review of Respiratory Disease·R M Cherniack, M B Raber
Sep 7, 1968·British Medical Journal·S E Davies

Related Concepts

Proxicromil sodium
Asthma
Bronchospasm, Exercise-Induced
Chromones
Double-Blind Method
Forced Expiratory Volume Function
Maximal Midexpiratory Flow Rate
Placebos
Vital Capacity

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