Effect of frailty and comorbidity on surgical contraindication in patients with localized prostate cancer (FRART-PC Study).

Urologic Oncology
Hirotake KodamaChikara Ohyama

Abstract

To determine how frailty and comorbidities affect surgical contraindication in patients with localized prostate cancer (CaP). We evaluated the effects of frailty in 479 patients with localized CaP who were treated with robot-assisted radical prostatectomy (RARP), or radiotherapy (RT) eligible for surgery (RT-nonfrail), or those with RT ineligible for surgery due to frailty or comorbidity (RT-frail) from February 2017 to April 2020. We retrospectively compared the geriatric 8 screening (G8) scores between patients with surgical indications (RARP and RT-nonfrail groups) and those with surgical contraindications (RT-frail group). The effect of G8 score in the RT-frail groups was investigated using multivariate logistic regression analysis. We developed and validated a nomogram for surgical contraindication in patients with localized CaP. The median age of patients was 70 years. There were 256, 60, and 163 patients in the RARP, RT-nonfrail, and RT-frail, respectively. The G8 score in the RARP and RT-nonfrail groups was significantly higher than in the RT-frail group (15 vs. 14, respectively, P < 0.001). Age, comorbidities (cerebrocardiovascular disease or chronic respiratory disease), and G8 score were significantly associated with...Continue Reading

References

Oct 2, 2008·BMC Geriatrics·Samuel D SearleKenneth Rockwood
Feb 23, 2010·CA: a Cancer Journal for Clinicians·Sumanta Kumar PalArti Hurria
Nov 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E David CrawfordAnthony V D'Amico
Oct 18, 2015·Clinics in Geriatric Medicine·Nicole T Townsend, Thomas N Robinson
Sep 14, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Takashi SaikaTadahiko Kikugawa
May 10, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahiro Kimura, Shin Egawa
May 23, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazuo HatanoKoichi Konoeda
Jun 12, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazuto ItoIsao Kurosawa
Sep 9, 2019·European Urology·MaryBeth B CulpAhmedin Jemal
Mar 24, 2020·Prostate Cancer and Prostatic Diseases·Giuseppe RosielloPierre I Karakiewicz
May 27, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazutaka OkitaChikara Ohyama
Jun 6, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Masaki MomotaChikara Ohyama

❮ Previous
Next ❯

Citations

Oct 14, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Shingo Hatakeyama, Chikara Ohyama
Oct 21, 2020·International Journal of Clinical Oncology·Tomoko HamayaChikara Ohyama
Mar 5, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Shingo Hatakeyama, Chikara Ohyama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.