Effect of frailty on short- and mid-term outcomes in vascular surgical patients

The British Journal of Surgery
G K AmblerP A Coughlin

Abstract

Frailty is a multidimensional vulnerability resulting from age-associated decline. The impact of frailty on outcomes was assessed in a cohort of vascular surgical patients. The study included patients aged over 65 years with length of hospital stay (LOS) greater than 2 days, who were admitted to a tertiary vascular unit over a single calendar year. Demographics, mode of admission, diagnosis, mortality, LOS and discharge destination were recorded, as well as a variety of frailty-specific characteristics. The impact of frailty on LOS, discharge destination, survival and readmission rate was assessed using multivariable regression techniques. The ability of the models to predict these outcomes was also assessed. In total, 413 patients of median age 77 years were followed for a median of 18 (range 12-24) months. The in-hospital, 3- and 12-month mortality rates were 3·6, 8·5 and 13·8 per cent respectively. Receiver operating characteristic (ROC) curve analysis revealed that frailty-based regression models were excellent predictors of 12-month mortality (area under the ROC curve (AUC) = 0·81), prolonged LOS (AUC = 0·79) and discharge to a care institution (AUC = 0·84). A simple additive frailty score using six key features retained s...Continue Reading

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Citations

Dec 1, 2015·Annals of Vascular Surgery·Eric S WiseColleen M Brophy
Dec 15, 2015·Seminars in Vascular Surgery·Larry W KraissBenjamin S Brooke
May 31, 2016·Annals of Vascular Surgery·Prudence J McRaeAlison M Mudge
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Apr 18, 2019·The Journal of Cardiovascular Surgery·Ryan PreeceIan Loftus
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Dec 19, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Thea KreutzburgChristian-Alexander Behrendt
Dec 31, 2019·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Graeme K AmblerChristopher P Twine
Jul 1, 2020·Annals of Vascular Surgery·Ellen A GilbertsonBenjamin S Brooke
Dec 29, 2018·Journal of Vascular Surgery·Laura M DrudiJonathan Afilalo
May 30, 2021·Experimental Gerontology·Manas Rane, Ariela R Orkaby
May 14, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Alexander Gombert
May 18, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Graeme K AmblerPatrick A Coughlin
Aug 9, 2021·American Journal of Surgery·Nicole IlonzoAgeliki Vouyouka

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