Effect of free fatty acids on bilirubin-albumin binding affinity and unbound bilirubin in premature infants.

JPEN. Journal of Parenteral and Enteral Nutrition
Sanjiv B Amin

Abstract

The author has previously shown that intravenous lipid intake may be associated with an increase in unbound bilirubin in infants < or =28 weeks gestational age. The objective of this study was to evaluate whether this increase in unbound bilirubin is mediated by free fatty acids and to examine the secondary effect of free fatty acids on bilirubin-albumin binding affinity. A prospective study was conducted to include 26 infants < or =32 weeks gestational age with indirect hyperbilirubinemia and receiving intravenous lipids during the first 10 postnatal days. Blood samples were collected for unbound bilirubin, binding affinity, and free fatty acid measurement at varying intravenous lipid intakes (1-3 g/kg/d). Regression analyses were performed to evaluate the roles of free fatty acids and binding affinity as mediators. Intravenous lipid intake was significantly associated with an increase in free fatty acids and unbound bilirubin in infants < or =28 weeks but not >28 weeks gestational age. In infants < or =28 weeks gestational age, each unit increase in free fatty acids was significantly associated with a decrease in binding affinity, which was significantly associated with an increase in unbound bilirubin. In infants < or =28 we...Continue Reading

References

Jul 1, 1977·The Journal of Pediatrics·A T ShennanA Angel
Sep 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Nakamura, Y Lee
Feb 1, 1987·Archives of Disease in Childhood·Y W BransD W Carrillo
Mar 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·M L SpearR A Polin
May 1, 1972·Acta paediatrica Scandinavica·H ThiessenR Brodersen
Aug 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·R Starinsky, E Shafrir
Jan 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·B T DoumasH G Biggs
Mar 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·M S DahnR Blasier
Sep 1, 1982·The American Journal of Clinical Nutrition·G J BurckartR A Helms
Jan 1, 1980·CRC Critical Reviews in Clinical Laboratory Sciences·R Brodersen
Feb 1, 1997·Journal of the American College of Nutrition·S RubenT Hegyi
Aug 7, 1999·Archives of Pediatrics & Adolescent Medicine·S B AminJ W Kendig
Aug 1, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·W Goessling, S D Zucker
Feb 3, 2005·Seminars in Perinatology·Sanjiv B Amin
Apr 22, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Sanjiv B AminRonnie Guillet
Jul 28, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·John A Kerner, Robert L Poole
Oct 31, 2006·Clinical Biochemistry·Charles E AhlforsUNKNOWN National Institute of Child Health and Development (NICHD) Neonatal Research Network
Feb 27, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·C E AhlforsA E Parker

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Citations

Mar 7, 2014·The New England Journal of Medicine·Jon F Watchko, Claudio Tiribelli
Oct 12, 2014·Seminars in Perinatology·Christian V Hulzebos, Peter H Dijk
Jun 7, 2011·Seminars in Perinatology·Sanjiv B Amin, Angelo A Lamola
Apr 2, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Bryan D HayesUNKNOWN Lipid Emulsion Workgroup
May 29, 2016·Clinics in Perinatology·Sanjiv B Amin
Mar 10, 2015·Biochimica Et Biophysica Acta·Pavlína Novotná, Marie Urbanová
Nov 30, 2014·Seminars in Fetal & Neonatal Medicine·Ichiro MoriokaHajime Nakamura
Apr 6, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Thomas HegyiWilliam Oh
Jul 1, 2011·Annals of Nutrition & Metabolism·Willemijn E CorpeleijnJohannes B van Goudoever
Mar 8, 2012·Clinical Chemistry·Andrew H HuberAlan M Kleinfeld
Jul 4, 2018·Pediatric Research·Charles E AhlforsDavid K Stevenson
Jun 15, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Thomas HegyiWilliam Oh
Mar 7, 2014·The New England Journal of Medicine·Deepraj HegdeSaurabh Mutha
Nov 15, 2017·The Journal of Pediatrics·Sanjiv B Amin, Hongyue Wang
Jan 20, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Shintaro IchimuraYasumasa Yamada

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