Effect of frozen storage on the creep behavior of human intervertebral discs

Spine
N DhillonJ C Lotz

Abstract

A biomechanical study of the compressive creep behavior of the human intervertebral disc before and after frozen storage. To determine whether frozen storage alters the time-dependent response of the intact human intervertebral disc. The biomechanical properties of the intervertebral disc are generally determined using specimens that have been previously frozen. Although it is well established that freezing does not alter the elastic response of the disc, recent data demonstrate that freezing permanently alters the time-dependent mechanical behavior of porcine discs. Twenty lumbar motion segments from 10 human spines were harvested between 12 and 36 hours postmortem. The specimens were randomly assigned to one of two groups: Group 1 was tested promptly, stored frozen for 3 weeks, then thawed, and tested a second time; Group 2 was stored frozen for 3 weeks, thawed, and then tested. Each specimen was subjected to 5 cycles of compressive creep under 1 MPa for 20 minutes, followed by a 40-minute recovery under no load. After testing each specimen was graded on a degeneration scale. A fluid transport model was used to parameterize the creep data. There was no statistically significant effect of freezing on the elastic or creep respo...Continue Reading

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Citations

Nov 8, 2003·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·O IzambertF Lavaste
Jul 10, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ulrich SchreiberRudolf Beisse
Jul 1, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Philippe GédetStephen J Ferguson
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Apr 24, 2004·Spine·Wafa TawackoliMichael A K Liebschner
Sep 17, 2005·Spine·Albert J van der VeenJaap H van Dieën
Dec 2, 2005·Spine·Fengdong ZhaoMichael A Adams
Jul 4, 2006·Spine·Jaap H van DieënIdsart Kingma
Jul 11, 2007·Spine·Andrzej S PrzybylaMichael A Adams
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