Effect of FTO rs9930506 on obesity and interaction of the gene variants with dietary protein and vitamin E on C-reactive protein levels in multi-ethnic Malaysian adults

Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association
S R MitraF Amini

Abstract

Individual variations of obesity-related traits can be a consequence of dietary influence on gene variants. This cross-sectional study aimed to evaluate (i) the effect of FTO rs9930506 on obesity and related parameters and (ii) the influence of diet on the above association in Malaysian adults. In total, 79 obese and 99 nonobese Malaysian adults were recruited. In comparison with Chinese and Malays, Indians had significantly higher waist circumference (P ≤ 0.001 and P = 0.016), waist-hip ratio (P = 0.001 and P < 0.001), body fat percentage (P = 0.001 and P = 0.042), fasting insulin (P = 0.001 and P = 0.001), homeostatic model assessment-insulin resistance (P = 0.001 and P = 0.001) and lower high-density lipoprotein-cholesterol levels (P < 0.001 and P < 0.001), respectively. Indians consumed significantly lower dietary cholesterol (P = 0.002), percentage energy from protein (P < 0.001) and higher fibre (P = 0.006) compared to the other two groups. Malaysian Indians expressed the highest risk allele frequency (G) of FTO rs9930506 compared to the Malays and the Chinese (P < 0.001). No significant association was found between FTO rs9930506 and obesity (dominant model). Risk allele carriers (G) consumed significantly lower vitamin ...Continue Reading

References

Sep 19, 2000·Medicine and Science in Sports and Exercise·B E AinsworthA S Leon
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Nov 16, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A MartiJ A Martínez
Mar 9, 2005·Annals of the New York Academy of Sciences·Uma Singh, Ishwarlal Jialal
May 3, 2005·Diabetologia·H Kolb, T Mandrup-Poulsen
May 15, 2007·Nature Genetics·Christian DinaPhilippe Froguel
Dec 7, 2007·Molecular Genetics and Metabolism·Armand PeetersWim Van Hul
Dec 17, 2008·The New England Journal of Medicine·Joanne E CecilColin N A Palmer
Apr 17, 2009·Current Opinion in Lipidology·Sridevi DevarajIshwarlal Jialal
Jun 1, 2010·European Journal of Human Genetics : EJHG·Tea Berulava, Bernhard Horsthemke
Jul 24, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hye-Ja LeeJihyun Song
Feb 8, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·S D ReesT H Jafar
Aug 6, 2011·Metabolic Syndrome and Related Disorders·Andrew K G TanSteven T Yen
Jan 12, 2012·Genomics·Markus Sällman AlménHelgi B Schiöth
Mar 29, 2012·Experimental Diabetes Research·Federica SentinelliMarco Giorgio Baroni
Aug 23, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Y D ApalasamyZ Mohamed
May 22, 2013·Journal of Nutrigenetics and Nutrigenomics·Thais SteemburgoJose Alfredo Martínez
Mar 14, 2014·Circulation. Cardiovascular Genetics·Jaana GustavssonFredrik Nyberg
Apr 5, 2014·Indian Journal of Endocrinology and Metabolism·Namita MahalleMohan V Kulkarni
Feb 2, 2016·PloS One·Anna-Lena VolckmarAnke Hinney
May 12, 2016·Clinics·Francisco Antonio Helfenstein Fonseca, Maria Cristina de Oliveira Izar
Jun 1, 2016·The Indian Journal of Medical Research·Malgorzata WrzosekGrażyna Nowicka
Jun 23, 2016·International Journal of Preventive Medicine·Norfazilah AhmadHasanain Faisal Ghazi
Apr 8, 2017·International Journal of Molecular Sciences·Yoriko Heianza, Lu Qi
Sep 2, 2017·Journal of Biomedical Science·Yuling ZhouCraig S McLachlan

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Citations

Sep 11, 2019·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·S C Langley-Evans
Dec 20, 2019·Biomolecular Concepts·S DoaeiS Mirzaei Dahka

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