Effect of Fucoidan on Anterior Cruciate Ligament Transection and Medial Meniscectomy Induced Osteoarthritis in High-Fat Diet-Induced Obese Rats

Nutrients
Sabri SudirmanZwe-Ling Kong

Abstract

Osteoarthritis (OA) has become one of the most common disabilities among elders, especially in females. Obesity and mechanical injuries caused by OA are attributed to joint loading, cartilage disintegration, and bone loss, as well as inflammation. Pharmacological and non-pharmacological treatments can be used for OA. Fucoidan possesses several bioactivities such as antitumor, antiviral, anticoagulation, anti-obesity, and immunomodulation. This study aims to investigate the effect of fucoidan in surgery-induced OA on rats with diet-induced obesity. OA was induced by an anterior cruciate ligament transection and a partial medial meniscectomy (ACLT + MMx). The male SD rats were fed with a high-fat diet (HFD) for 4 weeks to induce obesity before causing ACLT + MMx to induce OA. The OA rats were administered with intragastric water or fucoidan in three different concentrations (32 mg/kg, 64 mg/kg, and 320 mg/kg) after the surgeries for 40 days with an HFD. We observed that the swelling in the knee joint was alleviated and the hind paw weight distribution was rectified after feeding them with fucoidan and that there was no significant effect on the weight gain and feed intake. Fucoidan administration indicated no significant variatio...Continue Reading

References

Jul 15, 1994·Annals of Internal Medicine·D W Puett, M R Griffin
Oct 18, 2000·Annals of Internal Medicine·D T FelsonJ F Fries
Sep 11, 2001·Biochemical and Biophysical Research Communications·Y FigenschauB Sveinbjörnsson
Dec 25, 2002·Clinical Biochemistry·Metin OzataI Caglayan Ozdemir
Mar 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Jane V Higdon, Balz Frei
Nov 6, 2003·Sports Medicine·Hugh P JonesGeorge A C Murrell
Nov 13, 2003·Arthritis and Rheumatism·Hélène DumondPascale Pottie
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Cynthia J Stein, Graham A Colditz
Jun 30, 2005·Arthritis and Rheumatism·Stephen P MessierPaul DeVita
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Peter S BurrageConstance E Brinckerhoff
Oct 26, 2005·Osteoarthritis and Cartilage·K P H PritzkerW B van den Berg
Jun 8, 2006·Biochemical and Biophysical Research Communications·Jin Won YangKeon Wook Kang
Oct 14, 2006·Annals of the Rheumatic Diseases·P PottieF Berenbaum
Nov 23, 2006·Journal of Endocrinological Investigation·K EspositoD Giugliano
Feb 20, 2007·Current Drug Targets·Y Henrotin, B Kurz
Sep 1, 2007·The American Journal of Sports Medicine·L Stefan LohmanderEwa M Roos
Aug 30, 2008·Osteoarthritis and Cartilage·S KrasnokutskyS B Abramson
Jun 3, 2009·Annals of the Rheumatic Diseases·Erlangga YusufMargreet Kloppenburg
Mar 23, 2010·Deutsches Ärzteblatt International·Joern W-P MichaelPeer Eysel
May 18, 2010·Journal of Ethnopharmacology·Adejuwon Adewale AdeneyeEsther Oluwatoyin Agbaje
Jul 22, 2010·Pharmaceutical Biology·Ling HuangYonghong Liu
Dec 15, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A G DullooY Schutz
Jan 13, 2011·BMJ : British Medical Journal·Sven TrellePeter Jüni
Apr 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Emanuela Ricciotti, Garret A FitzGerald
May 17, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hye Young ParkYung Hyun Choi
Jun 21, 2011·International Journal of Molecular Sciences·Alba Fernández-SánchezJosé A Morales-González
May 12, 2012·Arthritis and Rheumatism·Craig R LouerFarshid Guilak
Dec 1, 2012·Osteoarthritis and Cartilage·F Berenbaum
Apr 13, 2013·Phytotherapy Research : PTR·Mi-Ja KimJin-Sil Lee
Jul 19, 2014·World Journal of Orthopedics·Thitiya Poonpet, Sittisak Honsawek
Feb 11, 2015·Osteoarthritis and Cartilage·K H CollinsW Herzog
Feb 17, 2015·World Journal of Clinical Cases·Kenton H FibelBrian C Halpern

❮ Previous
Next ❯

Citations

Mar 5, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kai HuangLi-Dong Wu
Feb 18, 2021·Carbohydrate Polymers·Carlos Vaamonde-GarcíaRosa Meijide-Faílde
May 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sabri SudirmanZwe-Ling Kong
Jun 27, 2021·Bone·Ioanna PapathanasiouAspasia Tsezou

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
MDA

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here