Effect of furazolidone on sister-chromatid exchanges, cell proliferation kinetics, and mitotic index in vivo and in vitro

Journal of Toxicology and Environmental Health
E Madrigal-BujaidarG Chamorro

Abstract

Furazolidone is an antimicrobial compound used in human and veterinary medicine. The aim of this investigation was to determine its genotoxic capacity in vitro and in vivo. We used the human lymphocyte culture system to detect the effect of 2.0, 4.0, 6.0, 8.0, or 10.0 micrograms/ml, and the mouse bone marrow assay to determine the effect of 8.6, 30.0, or 75.0 mg/kg furazolidone. In both systems we determined the frequency of sister-chromatid exchanges (SCE), the cell proliferation kinetics (CPK), and the mitotic index (MI). The in vitro results showed a significant SCE increase starting from the second dose tested and a CPK and MI decrease starting from the third dose. The in vivo results showed a SCE increase with the two high doses tested, but no significant modification was found in the CPK and MI with the three doses tested in the experiment.

References

Feb 1, 1977·Chemico-biological Interactions·P L Olive, D R McCalla
Jun 16, 1992·Mutation Research·P Morales-RamírezM Salazar-Jacobo
Sep 1, 1992·Journal of Gastroenterology and Hepatology·Z T Zheng, Y B Wang
Apr 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·B H Ali
Apr 1, 1991·Journal of Toxicology and Environmental Health·E Madrigal-BujaidarS Díaz Barriga-Arceo
Feb 17, 1968·Lancet·R N ChaudhuriP Manji
Jan 1, 1983·Environmental Mutagenesis·D R McCalla
Aug 1, 1983·Chemico-biological Interactions·S N ChatterjeeJ Basak
Oct 1, 1983·Scandinavian Journal of Clinical and Laboratory Investigation·K JaakkolaA U Arstila
Dec 1, 1983·Archives of Toxicology·D Lorke
Aug 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L A HoogenboomJ van Rhijn
May 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I De AngelisA Stammati
Jul 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·O VincentiniF Zucco

❮ Previous
Next ❯

Citations

Mar 30, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sandra Gómez-ArroyoMaria Elena Campos Aldrete
Jan 18, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Angelo ZulloVincenzo De Francesco
Nov 11, 2014·Helicobacter·Chuan Xie, Nong-Hua Lu
Aug 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chongshan DaiShusheng Tang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Food Microbiology
J RaipulisP Semjonovs
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Canxia XuHuifang Zou
Digestive Diseases and Sciences
Vincenzo De FrancescoAngelo Zullo
© 2021 Meta ULC. All rights reserved