PMID: 590565Nov 1, 1977

Effect of GABA and phenybut on the neuronal activity of the cortex and potentials of the spinal roots

Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova
A A Aleksandrov, U t Van Nguyen

Abstract

The effects of GABA AND PHENYBUT (BEta-phenyl-gamma-aminobutyric acid) on the dorsal (DRP) and ventral (VPR) root potentials were studied in the isolated frog spinal cord. The direct action of these agents on the neuronal membranes was studied by means of the microiontophoretic method in the cat cerebral cortex. Phenybut, like GABA, SUPPRESSES DRP and VRP at the spinal cord level, but it prolongs the duration of DRP and VRP rising phase and at the same time depresses the VR reflexes. Phenybut microiontophoretic application does not considerably affect the neuronal activity whereas GABA exerts an obvious inhibitory action. Differences in the mechanisms of GABA and phenybut actions on the c. n. s. elements are discussed.

Related Concepts

Aminobutyrates
Salientia
Felis catus
Electrophysiology (Science)
Gamma-Aminobutyric Acid, Zinc Salt (2:1)
Motor Cortex
Afferent Neuron
Neurons, Efferent
Reaction Time
Reflex Action

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