Effect of GABA(B) receptors on synaptic interactions in dentate gyrus granule neurons of the rat

Neuroscience
S Wang, J M Wojtowicz

Abstract

Dendritic arborization permits convergence of synaptic inputs and their integration in single neurons. The granule neuron in the dentate gyrus represents a relatively simple example where anatomically and functionally distinct medial and lateral perforant pathways terminate on different regions of the dendritic tree. High-frequency stimulation of either pathway alone results in the induction of long-term potentiation. However, whether the potentiated synapses in different parts of the dendrites interact is not known. In this study we have compared long-term potentiation and synaptic interactions in the lateral and medial perforant pathways in the "disinhibited" hippocampal slice preparation in the presence of the GABA(A) receptor blocker bicuculline. The data show that the magnitude of long-term potentiation induced by tetanic stimulation was similar in both pathways, but differences between the two pathways were revealed after two or more tetanizations. A significantly smaller capacity for further long-term potentiation in the lateral, as compared to the medial, perforant pathway was found and can be attributed to stronger postsynaptic GABA(B) inhibition in distal dendrites of granule neurons. Blockade of GABA(B) inhibition wi...Continue Reading

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May 22, 1998·Journal of Cardiovascular Pharmacology·T Yamamoto, H Uemura
Mar 8, 2006·Reviews in the Neurosciences·Rachel D SamsonDenis Paré
Jan 29, 2011·Neural Networks : the Official Journal of the International Neural Network Society·Hatsuo Hayashi, Yukihiro Nonaka
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Jun 2, 2001·Journal of Neurophysiology·J S SnyderJ M Wojtowicz

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