Effect of gadolinium chelate contrast agents on diffusion weighted MR imaging of the liver, spleen, pancreas and kidney at 3 T

European Journal of Radiology
Carolyn Lee WangElmar M Merkle

Abstract

To retrospectively test the null hypotheses that the qualitative appearance of DWI and the signal intensity values in DWI and corresponding ADC values of the liver, spleen, pancreas and kidneys are identical before and after the administration of gadolinium. Following IRB approval, DWI was acquired in 50 patients (25 male; mean age 54.9 years) prior to and after contrast administration, using single-shot echo planar imaging with b-values of 50 s/mm2 and 800 s/mm2 at 3 T. Binomial analysis was used to determine which image set was more significantly preferred in conveying the diffusion information. Pre- and post-gadolinium DWI and ADC values of corresponding regions of each organ were analyzed using standardized signal intensity measurements. Pre-contrast DWI images of the liver, spleen, and pancreas were preferred 52%, 49%, and 58%, respectively, with none of the differences being statistically significant. DWI of the kidneys was preferred on pre-contrast images in 83% (p<0.001). In the liver and spleen, contrast caused a significant increase in the post-contrast DWI signal intensity values at b=50 (p<0.02) and b=800 (p<0.05) but had no statistically significant effect on the ADC value (p>0.40). Pancreatic DWI signal intensity ...Continue Reading

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Citations

Jun 4, 2014·Radiologic Clinics of North America·Kumar Sandrasegaran
Aug 19, 2014·Critical Reviews in Oncology/hematology·Truong Luong Francis NguyenChristine Hoeffel
Dec 23, 2014·Radiology·Matthias BarralPhilippe Soyer
Apr 10, 2018·AJR. American Journal of Roentgenology·Dong Kyu KimYong Eun Chung
Oct 27, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Fumin GuoGrace Parraga
Jul 19, 2013·Neurology India·Yad Ram YadavYatin Kher
Aug 21, 2013·Journal of Magnetic Resonance Imaging : JMRI·Rajpaul Attariwala, Wayne Picker
Mar 10, 2015·Polish journal of radiology·Onur TutarCanan Akman
May 29, 2013·Journal of Magnetic Resonance Imaging : JMRI·Nicola GaleaBachir Taouli

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