Effect of galantamine hydrobromide in chronic fatigue syndrome: a randomized controlled trial

JAMA : the Journal of the American Medical Association
C V Russell BlackerTauhid Ali

Abstract

There is no established pharmacological treatment for the core symptoms of chronic fatigue syndrome (CFS). Galantamine hydrobromide, an acetyl cholesterone inhibitor, has pharmacological properties that might benefit patients with CFS. To compare the efficacy and tolerability of galantamine hydrobromide in patients with CFS. Randomized, double-blind trial conducted June 1997 through July 1999 at 35 outpatient centers in the United Kingdom (n = 17), United States (n = 14), the Netherlands (n = 2), Sweden (n = 1), and Belgium (n = 1) involving 434 patients with a clinical diagnosis of CFS (modified US Centers for Disease Control and Prevention criteria). A total of 89 patients were randomly assigned to receive 2.5 mg of galantamine hydrobromide; 86 patients, 5.0 mg; 91 patients, 7.5 mg; and 86 patients, 10 mg (these patients received medicine in the tablet form 3 times per day); a total of 82 patients received matching placebo tablets 3 times per day. The primary efficacy variable was the global change on the Clinician Global Impression Scale after 4, 8, 12, and 16 weeks of treatment. Secondary outcomes were changes in core symptoms of CFS on the Chalder Fatigue Rating Scale, the Fibromyalgia Impact Questionnaire, and the Pittsbu...Continue Reading

Citations

Jun 12, 2009·Expert Opinion on Pharmacotherapy·Chi-Un PaeAlessandro Serretti
Jan 31, 2006·Lancet·Judith B PrinsGijs Bleijenberg
May 28, 2016·Clinical Therapeutics·Ansel CollatzSonya M Marshall-Gradisnik
Mar 14, 2007·Clinical Psychology Review·Stefan M van GeelenWietse Kuis

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