Effect of gallium nitrate on experimental autoimmune uveitis

Experimental Eye Research
M C LobanoffS M Whitcup

Abstract

Gallium nitrate (GN) has been shown to inhibit T cell-mediated inflammatory disease. The purpose of our study was to test the effect of gallium nitrate (GN) on experimental autoimmune uveitis (EAU). Experimental autoimmune uveitis was induced in male Lewis rats immunized with retinal S-antigen. Rats received subcutaneous injections of GN or saline one day prior to immunization and 1, 4, 7, 10, 13, 16, and 19 days after immunization. Ocular inflammation was graded clinically and histologically by masked observers, and in vitro assays of cell-mediated and humoral immunity were performed. GN significantly inhibited the development of EAU graded clinically (P = 0.001) and histologically (P = 0.002). Treatment with GN also resulted in a small (30-41%) decrease in the lymphocyte responses to retinal S-Antigen and a small (12-37%) reduction in antibody production to S-antigen. These data show that GN suppresses the development of EAU, and inhibits both lymphocyte proliferative responses to antigen and antibody production.

References

Jul 1, 1992·Journal of Neuroimmunology·C WhitacreN Gerber
Sep 1, 1991·Transplantation·C P HerbortI Pastan
Apr 1, 1985·Clinical Immunology and Immunopathology·C C ChanD BenEzra
Oct 1, 1985·Archives of Ophthalmology·R B NussenblattA G Palestine
Jan 1, 1982·Ophthalmic Research·C DoreyJ P Faure
Jun 1, 1982·European Journal of Immunology·M C Salinas-CarmonaI Gery
Apr 1, 1981·The Journal of Clinical Investigation·R B NussenblattI Gery

❮ Previous
Next ❯

Citations

Sep 28, 2018·Science Translational Medicine·Christopher H GossPradeep K Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.