Effect of gamma irradiation on structure, physicochemical and immunomodulatory properties of Astragalus polysaccharides

International Journal of Biological Macromolecules
Lina RenGuanghong Zhou

Abstract

Astragalus polysaccharides (APS) were treated with different gamma irradiation doses (10, 25, 50, 100 and 150 kGy) to investigate the effects of gamma radiation processing on structure, physicochemical and immunomodulatory properties. The results revealed both the number-average and weight-average molecular weight of APS significantly decreased with increasing irradiation dose, whereas the solubility was increased after irradiation. A decrease in the apparent viscosity, as well as an increase in amount of small fragments of APS granules was also observed with increasing irradiation dose. FT-IR spectra indicated that gamma irradiation introduced no significant changes into the functional group status of APS. High irradiation dose (>50 kGy) caused a significant increase of yellowness and a slightly decrease of thermal stability of APS. Further, the immunomodulatory activity of irradiated APS was evaluated on Caco2 cells. APS irradiated at dose of 25 kGy exhibited the highest ability to induce nitric oxide production and up-regulate the mRNA expression of inflammatory cytokines, occludin, zonula occludens protein-1 (ZO-1) and toll-like receptor 4 (TLR4), as well as the protein expression of ZO-1 and TLR4. These findings indicate t...Continue Reading

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Citations

Sep 11, 2019·Chinese Journal of Integrative Medicine·Yu-Tong Liu, Wen-Liang Lv
Oct 11, 2020·Applied Microbiology and Biotechnology·Luis A Cancino-CastilloMaribel Jiménez-Fernández
Apr 25, 2020·Journal of Ethnopharmacology·Zhejie ChenYitao Wang
Oct 16, 2020·International Journal of Biological Macromolecules·Jie DengYuanming Sun

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