Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice

British Journal of Pharmacology
N ChairungsrilerdY Ohizumi

Abstract

1. Intracerebronventricular (i.c.v.) injection of gamma-mangostin (10-40 nmol/mouse), a major compound of the fruit hull of Garcinia mangostana Lin., like ketanserin (10, 20 nmol/mouse, i.c.v.) inhibited 5-fluoro-alpha-methyltryptamine (5-FMT) (45 mg kg(-1), i.p.)-induced head-twitch response in mice in the presence or absence of citalopram (a 5-hydroxytryptamine (5-HT)-uptake inhibitor). 2. Neither the 5-FMT- nor the 8-hydroxy-2-(di-n-propylamino)tetralin (5-HT1A-agonist)-induced 5-HT syndrome (head weaving and hindlimb abduction) was affected by gamma-mangostin or ketanserin. 3. The locomotor activity stimulated by 5-FMT through the activation of alpha1-adrenoceptors did not alter in the presence of gamma-mangostin. 4. 5-HT-induced inositol phosphates accumulation in mouse brain slices was abolished by ketanserin. Gamma-mangostin caused a concentration-dependent inhibition of the inositol phosphates accumulation. 5. Gamma-mangostin caused a concentration-dependent inhibition of the binding of [3H]-spiperone, a specific 5-HT2A receptor antagonist, to mouse brain membranes. 6. Kinetic analysis of the [3H]-spiperone binding revealed that gamma-mangostin increased the Kd value without affecting the Bmax value, indicating the mode...Continue Reading

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Citations

Mar 10, 2004·Pharmacology, Biochemistry, and Behavior·Kuldip D DaveVincent J Aloyo
Mar 29, 2011·Journal of Ethnopharmacology·Monrudee SukmaBoonyong Tantisira
Aug 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·José Pedraza-ChaverriJazmin M Pérez-Rojas
Jul 5, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui-Fang Chang, Ling-Ling Yang
Dec 9, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui-Fang ChangLing-Ling Yang
Jan 28, 2009·Phytotherapy Research : PTR·Dmitriy ObolskiyMichael Heinrich

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