Abstract
We previously showed that ganhuangenin (GHG) has beneficial antioxidative properties against lipid peroxidation in tissues of Sprague-Dawley (SD) rats. In this study, the effect of GHG on immunoglobulin E (IgE), histamine and leukotriene B(4) (LTB(4)) levels of cells isolated from SD rats was examined with regard to the manifestation of the type I allergic reaction. We showed that GHG inhibited the IgE production of mesenteric lymph node (MLN) lymphocytes. In the presence or absence of concanavalin A (ConA), the concentration used did not exert a toxic effect against MLN lymphocytes. Interestingly, the increase in the IgE content and lipid peroxidation induced by ConA was alleviated in the presence of GHG. Moreover, GHG also inhibited histamine release from the peritoneal exudate cells stimulated with a calcium ionophore, A23187, or with the histamine releaser, compound 48/80. In the case of LTB(4), GHG markedly inhibited its release at a concentration of 100 microM. Thus, it is concluded that GHG may block the common pathway for the release of histamine and LTB(4), and that the IgE level is responsible for the lipid peroxidation induced by ConA.
References
Oct 1, 1992·Bone and Mineral·M L Brandi
Jun 1, 1991·The Journal of Allergy and Clinical Immunology·S VollenweiderC Hauser
Jan 1, 1990·Free Radical Biology & Medicine·A T CanadaR P Mason
Mar 13, 1987·Biochemical and Biophysical Research Communications·H KawabeO Hayaishi
Jul 1, 1987·Analytical Biochemistry·W S Powell
Jun 1, 1988·European Journal of Immunology·J PèneJ E De Vries
Jan 1, 1986·Respiration; International Review of Thoracic Diseases·S E DahlénP Hedqvist
Apr 1, 1985·Planta medica·Y KimuraS Arichi
Sep 1, 1971·Immunochemistry·E Engvall, P Perlmann
Mar 1, 1982·The Journal of Allergy and Clinical Immunology·M KalinerE A Ottesen
Jun 1, 1984·The Journal of Allergy and Clinical Immunology·F L PearceJ Bienenstock
Jul 17, 1980·Nature·A W Ford-HutchinsonM J Smith
Apr 1, 1983·Biochemical Pharmacology·B Havsteen
Jan 1, 1982·Chemical & Pharmaceutical Bulletin·Y KimuraH Okuda
Jun 1, 1994·In Vitro Cellular & Developmental Biology. Animal·B O LimM Sugano
Jan 1, 1994·Life Sciences·S Y NamgoongH P Kim
Jul 1, 1996·Journal of Biochemistry·K YamadaM Sugano
May 1, 1997·The Journal of Nutrition·B O LimM Sugano
Sep 10, 1999·Phytotherapy Research : PTR·B O LimD K Park
Jun 22, 2000·Phytotherapy Research : PTR·H Y ChoiD K Park
Jun 27, 2000·The Journal of Nutrition·B O LimG Fernandes
Jan 1, 1985·Planta·R Aloni, T Plotkin
Citations
Dec 25, 2002·Journal of Ethnopharmacology·Beong Ou Lim
Sep 3, 2003·Bioscience, Biotechnology, and Biochemistry·Beong Ou LimRyo Won Choue
Dec 30, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Po-Jung TsaiWen-Huey Wu
Sep 8, 2010·Journal of Ethnopharmacology·Jinkyung KimRyowon Choue
Feb 23, 2011·Phytotherapy Research : PTR·In Seok LeeRyowon Choue
Feb 14, 2017·Mediators of Inflammation·Xia ShenGang Zhang
Jul 6, 2019·Frontiers in Pharmacology·Lee Yen SimKhairana Husain