Effect of gastrin-17 on lower esophageal sphincter characteristics in man

Digestive Diseases and Sciences
J W StraathofA A Masclee

Abstract

We studied the effect of gastrin-17 on lower esophageal sphincter (LES) characteristics in man. Nine healthy volunteers participated in two experiments performed in random order during continuous infusion of saline (control) or gastrin-17 (15 pmol/kg/hr). LES pressure (LESP) and transient lower esophageal sphincter relaxations (TLESR), as most the important reflux mechanism, were measured with intraesophageal sleeve manometry combined with pH metry. Infusion of gastrin-17 resulted in plasma gastrin levels comparable to those reached after a mixed meal. During continuous gastrin infusion, LESP decreased significantly (P < 0.05) compared to control. The rate and duration of TLESR was not influenced by gastrin-17. Gastroesophageal reflux and the number of TLESR associated with reflux were significantly (P < 0.05) increased during gastrin infusion. These results suggest that in humans gastrin at physiological postprandial plasma concentrations decreases LESP, does not influence TLESR, but increases the percentage of TLESR associated with reflux.

Citations

Dec 3, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B MearadjiA A Masclee
Aug 15, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A A MascleeC B Lamers
Apr 12, 2003·Pharmacology & Toxicology·Theodore J Koh
Jul 1, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y-C SuC-M Jan
Oct 12, 1999·The American Journal of Physiology·L A BlackshawJ Dent
Aug 22, 2001·The American Journal of Gastroenterology·J W StraathofA A Masclee
Sep 3, 2003·Helicobacter·Shigemi Nakajima, Takanori Hattori
Dec 21, 2005·Basic & Clinical Pharmacology & Toxicology·Thierry Piche, Jean Paul Galmiche
Mar 1, 2008·Nature Reviews. Drug Discovery·Gareth J Sanger, Kevin Lee
May 1, 2008·Journal of Gastroenterology and Hepatology·Jun-Feng LiuQi-Zhang Wang
May 16, 2006·Digestive Diseases·Carmelo ScarpignatoFrancesco Di Mario
Jan 14, 2005·Gastroentérologie Clinique Et Biologique·Thierry Piche

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