PMID: 3758537Aug 1, 1986Paper

Effect of gavage vehicle on hepatotoxicity of carbon tetrachloride in CD-1 mice: corn oil versus Tween-60 aqueous emulsion

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
L M CondieJ P Bercz

Abstract

This investigation was conducted to evaluate the effect of gavage vehicles on altering the severity of the subchronic hepatotoxicity of carbon tetrachloride (CCl4). Male and female CD-1 mice were gavaged with 0, 1.2, 12, and 120 mg/kg CCl4 in either a corn oil or 1% Tween-60 vehicle once daily for 5 consecutive days per week for 90 days. The study revealed that the hepatotoxicity was greater in the mid- and high-dose groups of mice that had received CCl4 administered in corn oil. Increases in serum enzyme activities were detected in the mid-dose groups of mice that were gavaged with CCl4 in corn oil. The serum enzyme activities were significantly higher in the high-dose groups of animals in which CCl4 was administered in corn oil. Histopathological findings indicated that hepatocellular changes following the administration of CCl4 at the mid- and high-dose levels were more frequent and more severe when CCl4 was given in corn oil than when it was administered in Tween-60. The experimental findings indicate that the no-observed-adverse-effect level from CCl4 exposure was lowered by an order of magnitude (from 12 to 1.2 mg/kg) and that the hepatotoxicity of CCl4 was enhanced in the high-dose treatment groups when corn oil was empl...Continue Reading

Citations

Aug 11, 2007·Journal of Occupational Health·Kasuke NaganoShoji Fukushima
Dec 14, 2011·Toxicology·Sathanandam S AnandScott E Loveless
Sep 1, 1992·Journal of Toxicology and Environmental Health·E BermanJ E Simmons
Jan 1, 1995·Journal of Toxicology and Environmental Health·K P KoporecJ V Bruckner
Aug 8, 1997·Journal of Toxicology and Environmental Health·P Raymond, G L Plaa
Jan 1, 1989·Journal of Toxicology and Environmental Health·J E Simmons, E Berman
Sep 1, 1993·Journal of Toxicology and Environmental Health·M K SelgradeJ W Allis
Jun 1, 1991·Journal of Applied Toxicology : JAT·K E TomaszewskiP Jeffrey
Sep 1, 1995·Journal of Applied Toxicology : JAT·M Y FarooquiA Tamez
Jan 1, 1988·Drug and Chemical Toxicology·M EmaS Kanoh
Jun 1, 1991·Journal of Applied Toxicology : JAT·B A MerrickL W Condie
Jan 1, 1990·Toxicology and Applied Pharmacology·H J KimJ V Bruckner

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