Effect of gefarnate on the ocular surface in squirrel monkeys

Cornea
Hiroshi ToshidaRoger W Beuerman

Abstract

To investigate the ability of gefarnate (geranyl farnesylacetate) to stimulate goblet cell function in the primate eye after a mild alkali injury of the tarsal conjunctiva. A bilateral injury was created on the conjunctival surface of the lower eye lid of squirrel monkeys by means of a 30-second application of a 4-mm diameter piece of filter paper wetted with 0.5% NaOH. Gefarnate drops (1%) were administered to one eye of each monkey and vehicle alone in the contralateral eye six times a day, 5 days a week for 4 weeks. Slit-lamp biomicroscopy, impression cytology staining of the ocular surface, fluorescein and rose bengal staining, and Western blot for mucin were performed before injury and weekly thereafter. Light microscopy was used to evaluate the lower conjunctiva. Topical application of gefarnate was not associated with any adverse ocular surface effects. Goblet cell repopulation after injury was significantly greater in the gefarnate-treated eyes compared with the vehicle-treated eyes. In the gefarnate-treated eyes, tear mucin content was significantly greater at 1 week after injury. Fluorescein staining was significantly reduced at 3 weeks after injury, and rose bengal staining was significantly reduced in the area of th...Continue Reading

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Citations

Apr 27, 2004·Experimental Eye Research·Margarita CalongeJosé M Herreras
Aug 5, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Padmapriya Ramamoorthy, Jason J Nichols
Sep 28, 2007·Investigative Ophthalmology & Visual Science·Hiroshi ToshidaAkira Murakami
Feb 17, 2009·Investigative Ophthalmology & Visual Science·Hiroshi ToshidaAkira Murakami
Oct 12, 2012·Clinical Ophthalmology·Akito OdakaAkira Murakami
Jul 1, 2008·Expert Review of Clinical Immunology·Susumu Sugai, Yasafumi Masaki
Mar 13, 2016·Survey of Ophthalmology·William StevensonMingwu Wang
Aug 24, 2007·Seminars in Arthritis and Rheumatism·Aikaterini Thanou-Stavraki, Judith A James
Jun 29, 2004·Progress in Retinal and Eye Research·Michael E Johnson, Paul J Murphy
Jan 12, 2007·The Ocular Surface·Ilene K GipsonPablo Argüeso

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