Effect of Gender on the Outcome of Patients Receiving Immune Checkpoint Inhibitors for Advanced Cancer: A Systematic Review and Meta-Analysis of Phase III Randomized Clinical Trials

Journal of Clinical Medicine
Antonino GrassadoniaNicola Tinari


Evidence has recently emerged on the influence of gender on the immune system. In this systematic review and meta-analysis of phase III randomized clinical trials (RCTs), we explored the impact of gender on survival in patients with advanced cancer treated with immune checkpoint inhibitors (ICIs). We performed a comprehensive search of the literature updated to April 2018, including the Cochrane Central Register of Controlled Trials, PubMed, and EMBASE. We extracted data on study characteristics and risk of bias in duplicate. Of 423 unique citations, 21 RCTs were included, inherently to 12,635 patients. Both males and females showed reduced risk of death associated with ICIs use (HR 0.73, p < 0.001 and HR 0.77, p < 0.001, respectively). Subgroup analyses by specific ICI showed similar OS in both genders for anti-PD-1/PDL-1. Anti-CTLA-4 use was associated with longer OS in men only (HR 0.77, p < 0.012), with the exception of melanoma (in women, HR 0.80, p = 0.006). PFS was longer in men than in women (HR 0.67, p < 0.001 and HR 0.77, p = 0.100, respectively). Conclusively, ICIs use was associated with more favorable outcomes in men, particularly for anti-CTLA-4 agents. In melanoma, not gender-related factors may influence the ant...Continue Reading


Feb 12, 2002·Statistics in Medicine·Hans C van HouwelingenTheo Stijnen
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
May 5, 2006·Nature Reviews. Drug Discovery·Vera Regitz-Zagrosek
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon ReadFiona Powrie
Aug 30, 2008·Nature Reviews. Immunology·Eleanor N Fish
Jan 1, 2009·Advances in Experimental Medicine and Biology·Chang H Kim
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok
Nov 15, 2011·Journal of Autoimmunity·Olga L QuinteroJuan-Manuel Anaya
Feb 4, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L V RiellaA Chandraker
Dec 12, 2012·Frontiers in Genetics·M Tevfik Dorak, Ebru Karpuzoglu
Jan 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antoni RibasAxel Hauschild
Aug 16, 2013·Nature·Ludmil B AlexandrovMichael R Stratton
Nov 19, 2013·Trends in Immunology·J G Markle, E N Fish
Jun 27, 2014·The Journal of Infectious Diseases·Jan van Lunzen, Marcus Altfeld
Nov 18, 2014·The New England Journal of Medicine·Caroline RobertPaolo A Ascierto
Nov 20, 2014·The New England Journal of Medicine·Alexandra SnyderTimothy A Chan
Apr 22, 2015·The New England Journal of Medicine·Caroline RobertUNKNOWN KEYNOTE-006 investigators
May 9, 2015·World Journal of Gastroenterology : WJG·Sung-Eun KimMi-Kyung Sung
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Sep 26, 2015·The New England Journal of Medicine·Robert J MotzerUNKNOWN CheckMate 025 Investigators
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Oct 1, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Emanuele CrocettiUNKNOWN EUROCARE-5 Working Group:
Oct 21, 2015·Nature Reviews. Urology·Ilaria LuccaShahrokh F Shariat
Mar 16, 2016·Nature Reviews. Clinical Oncology·Danny N KhalilJedd D Wolchok
Jul 28, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin ReckDavid Spigel
Aug 23, 2016·Nature Reviews. Immunology·Sabra L Klein, Katie L Flanagan
Sep 3, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Juan Pablo Mackern-ObertiAlexis M Kalergis
Oct 11, 2016·The New England Journal of Medicine·Robert L FerrisMaura L Gillison
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Feb 18, 2017·The New England Journal of Medicine·Joaquim BellmuntUNKNOWN KEYNOTE-045 Investigators
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Oct 12, 2017·Cell Communication and Signaling : CCS·Sonali Bhattacharjee, Saikat Nandi
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