Effect of genetic polymorphisms involved in folate metabolism on the concentration of serum folate and plasma total homocysteine (p-tHcy) in healthy subjects after short-term folic acid supplementation: a randomized, double blind, crossover study

Genes & Nutrition
Rona CaboM Azam Mansoor

Abstract

Data on the effect of combined genetic polymorphisms, involved in folate metabolism, on the concentration of serum folate after folic acid supplementation are scarce. Therefore, we investigated the impact of seven gene polymorphisms on the concentration of serum folate and p-tHcy in healthy subjects after short-term folic acid supplementation. In a randomized, double blind, crossover study, apparently healthy subjects were given either 0.8 mg folic acid per day (n = 46) or placebo (n = 45) for 14 days. The washout period was 14 days. Fasting blood samples were collected on day 1, 15, 30 and 45. Data on subjects on folic acid supplementation (n = 91) and on placebo (n = 45) were used for the statistical analysis. The concentration of serum folate increased higher in subjects with higher age (53.5 ± 7.0 years) than in subjects with lower age (24.3 ± 3.2 years) after folic acid supplementation (p = 0.006). The baseline concentration of serum folate in subjects with polymorphism combination, reduced folate carrier protein, RFC1-80 GA and methylenetetrahydrofolate reductase, MTHFR677 CT+TT, was lower than RFC1-80 AA and MTHFR677 CT+TT (p = 0.002). After folic acid supplementation, a higher increase in the concentration of serum fola...Continue Reading

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Citations

Apr 18, 2003·Metabolism: Clinical and Experimental·Robert W PowersJames M Roberts
Feb 1, 2017·Genes & Nutrition·Jim KaputFabio Virgili
Nov 22, 2017·American Journal of Human Biology : the Official Journal of the Human Biology Council·Patrice JonesEmma Beckett
Jan 23, 2020·International Journal of Environmental Research and Public Health·Martina BarchittaAntonella Agodi
Jun 8, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Paul Haggarty
Jul 30, 2020·Medicina·Andrea Maugeri, Martina Barchitta
Sep 6, 2020·Journal of Clinical Medicine·Maša Vidmar GoljaIrena Mlinarič-Raščan
May 18, 2018·Open Life Sciences·Małgorza SzczukoEwa Stachowska

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