May 1, 1987

Effect of gentamicin on human blood cells metabolism as measured by microcalorimetry

Human Toxicology
L Nässberger, M Monti

Abstract

The effect of gentamicin on overall metabolism in human blood cells was studied by microcalorimetry. At concentrations above therapeutic levels, the drug induced an increase in heat production rate in red cells, whereas no effect was found at lower concentrations. The Na/K-pump was unaffected at any gentamicin concentration. A slight increase in heat production rate was noted in granulocytes when incubated with gentamicin at concentrations above therapeutic levels, otherwise no effect was recorded at lower concentrations. Lymphocytes were unaffected by gentamicin at any concentration. Microcalorimetry seems to be a suitable method for studying the effect of drugs on overall cell metabolism, and for evaluating the Na/K-pump activity.

  • References15
  • Citations4
  • References15
  • Citations4

Citations

Mentioned in this Paper

Metabolic Process, Cellular
Gentamicins
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Gentacycol
Granulocyte Count
Lymphoid Cells
Ouabain
Calorimetry
Metabolic Pathway
Gentamicin Measurement

About this Paper

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.