Effect of GFR on plasma N-terminal connective tissue growth factor (CTGF) concentrations

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Karin G GerritsenRobbert J Kok

Abstract

Connective tissue growth factor (CTGF) has a key role in the pathogenesis of renal and cardiac fibrosis. Its amino-terminal fragment (N-CTGF), the predominant form of CTGF detected in plasma, has a molecular weight in the middle molecular range (18 kDa). However, it is unknown whether N-CTGF is a uremic retention solute that accumulates in chronic kidney disease (CKD) due to decreased renal clearance and whether it can be removed by hemodiafiltration. 4 observational studies in patients and 2 pharmacokinetic studies in rodents. 4 single-center studies. First study (cross-sectional): 88 patients with CKD not receiving kidney replacement therapy. Second study (cross-sectional): 23 patients with end-stage kidney disease undergoing low-flux hemodialysis. Third study: 9 kidney transplant recipients before and 6 months after transplant. Fourth study: 11 low-flux hemodialysis patients and 12 hemodiafiltration patients before and after one dialysis session. First, second, and third study: (residual) glomerular filtration rate (GFR). Fourth study: dialysis modality. Plasma (N-)CTGF concentrations, measured by enzyme-linked immunosorbent assay. In patients with CKD, we observed an independent association between plasma CTGF level and est...Continue Reading

References

Dec 1, 1992·Kidney International·C VincentJ P Revillard
Feb 1, 1983·The American Journal of Medicine·G C VibertiH Keen
Feb 1, 1997·Journal of the American Society of Nephrology : JASN·G H VerseputH A Koomans
Apr 29, 1998·Kidney International·Y ItoR Goldschmeding
Apr 15, 1999·Journal of the American Society of Nephrology : JASN·E I ChristensenS K Moestrup
Mar 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·W LornoyP D'Haenens
Apr 5, 2003·Kidney International·Raymond VanholderUNKNOWN European Uremic Toxin Work Group (EUTox)
Nov 6, 2003·American Journal of Physiology. Renal Physiology·Zhonghua QiMatthew D Breyer
Mar 12, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Iwona CichaChristoph D Garlichs
Apr 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gary R Grotendorst, Matthew R Duncan
Apr 14, 2006·Kidney International·A Y-M Wang, K-N Lai
Aug 8, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·O ChengR B Mannon
Aug 16, 2006·Annals of Internal Medicine·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
May 18, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Denis FouqueRaymond Vanholder
Jun 8, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mausumee GuhaRama Natarajan
Mar 6, 2008·The Journal of Clinical Endocrinology and Metabolism·Ayad A JaffaUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Group
Mar 14, 2008·European Journal of Heart Failure·Norimichi KoitabashiMasahiko Kurabayashi
Dec 2, 2008·Acta Physiologica·A DanielsF A van Nieuwenhoven
Mar 4, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Tamara TurkRoel Goldschmeding
Jun 6, 2009·Pflügers Archiv : European journal of physiology·Erik Ilsø ChristensenRikke Nielsen
Aug 8, 2009·Journal of the American Society of Nephrology : JASN·Menaka SaravRichard J Quigg
Dec 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·E Lars PenneUNKNOWN CONTRAST investigators
Mar 20, 2010·American Journal of Physiology. Renal Physiology·Karin G GerritsenRoel Goldschmeding
Apr 16, 2010·Annals of Clinical Biochemistry·Osamu MiyazakiKazuhiko Takehara
May 1, 2010·Journal of Molecular and Cellular Cardiology·Pyoung Oh YoonWoo Jin Park
May 14, 2010·American Journal of Physiology. Renal Physiology·M E ChapmanD E Kohan
Jun 5, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Sharon G AdlerK Lea Sewell
Aug 7, 2010·Nephron. Experimental Nephrology·Yasuhiko ItoRoel Goldschmeding
Oct 23, 2010·The Journal of Biological Chemistry·Marcus PohlFranziska Theilig
May 21, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Amélie DendoovenRoel Goldschmeding

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Citations

Oct 23, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Michael BehnesUrsula Hoffmann
Feb 5, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lucas L FalkeTri Quang Nguyen
Oct 15, 2014·Nature Reviews. Nephrology·Helena M KokTri Q Nguyen
Apr 29, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marc HilhorstUNKNOWN Limburg Renal Registry
Sep 21, 2016·Journal of Cell Communication and Signaling·K G F GerritsenR J Kok
Aug 23, 2019·Scientific Reports·Hiroshi KinashiYasuhiko Ito
Aug 21, 2018·Inflammation and Regeneration·Naohiro TodaHideki Yokoi

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