Effect of ghrelin on glucose regulation in mice

American Journal of Physiology. Endocrinology and Metabolism
Shaji K ChackoAgneta L Sunehag

Abstract

Improvement of glucose metabolism after bariatric surgery appears to be from the composite effect of the alterations in multiple circulating gut hormone concentrations. However, their individual effect on glucose metabolism during different conditions is not clear. The objective of this study was to determine whether ghrelin has an impact on glycogenolysis, gluconeogenesis, and insulin sensitivity (using a mice model). Rate of appearance of glucose, glycogenolysis, and gluconeogenesis were measured in wild-type (WT), ghrelin knockout (ghrelin(-/-)), and growth hormone secretagogue receptor knockout (Ghsr(-/-)) mice in the postabsorptive state. The physiological nature of the fasting condition was ascertained by a short-term fast commenced immediately at the end of the dark cycle. Concentrations of glucose and insulin were measured, and insulin resistance and hepatic insulin sensitivity were calculated. Glucose concentrations were not different among the groups during the food-deprived period. However, plasma insulin concentrations were lower in the ghrelin(-/-) and Ghsr(-/-) than WT mice. The rates of gluconeogenesis, glycogenolysis, and indexes of insulin sensitivity were higher in the ghrelin(-/-) and Ghsr(-/-) than WT mice d...Continue Reading

References

May 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·E NäslundL Backman
Nov 1, 2000·Nature·M TschöpM L Heiman
Nov 29, 2001·The Journal of Biological Chemistry·Masahiro MurataKazuo Chihara
May 16, 2002·The Journal of Endocrinology·T HayashidaN Murakami
May 25, 2002·The New England Journal of Medicine·David E CummingsJonathan Q Purnell
Jul 11, 2002·Histochemistry and Cell Biology·Guido RindiEnrico Solcia
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Mohammed F SaadRima Boyadjian
Mar 19, 2003·European Journal of Clinical Investigation·O Ukkola
Apr 24, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Radhika MuzumdarNir Barzilai
Oct 31, 2003·European Journal of Endocrinology·Lucia BriatoreRenzo Cordera
Oct 31, 2003·Molecular and Cellular Biology·Yuxiang SunRoy G Smith
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yuxiang SunRoy G Smith
Apr 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Tracey McLaughlinDavid E Cummings
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Katherine E WortleyMark W Sleeman
Jul 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jens Juul Holst, Jesper Gromada
Jul 28, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M-S KimK-U Lee
Aug 26, 2004·American Journal of Physiology. Endocrinology and Metabolism·Rocco BarazzoniGianfranco Guarnieri
Sep 2, 2004·European Journal of Endocrinology·M Korbonits, A B Grossman
Sep 15, 2004·The Journal of Biological Chemistry·Roger Gutiérrez-JuárezLuciano Rossetti
Oct 14, 2004·JAMA : the Journal of the American Medical Association·Henry BuchwaldKaren Schoelles
Nov 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Carlotta GaunaAart Jan van der Lely
Oct 27, 2005·Diabetes·Alessandro PocaiLuciano Rossetti
Dec 3, 2005·The Journal of Clinical Investigation·Jeffrey M ZigmanJoel K Elmquist
Dec 3, 2005·The Journal of Clinical Investigation·Katherine E WortleyMark W Sleeman
Feb 18, 2006·Diabetologia·A C HeijboerE P M Corssmit
Jun 29, 2006·Laboratory Animals·J C MariniP J Garlick
Nov 29, 2007·The Journal of Clinical Endocrinology and Metabolism·Esben Thyssen VestergaardOle Schmitz
Jan 12, 2008·Journal of Applied Physiology·Shaji K ChackoMorey W Haymond

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Citations

Oct 9, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Geetali PradhanYuxiang Sun
Nov 26, 2015·Diabetes·Stephanie T ChungMorey W Haymond
Apr 8, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Shuang-Qi TangYang Lu
Apr 4, 2017·Endocrinology·Rebecca E HarveyMark W Sleeman
Jun 24, 2017·Journal of Molecular Endocrinology·Ting-Ting ZhouXu Shen
Jan 26, 2018·Basic & Clinical Pharmacology & Toxicology·Chonlaphat SukasemPenkhae Limsila
Oct 3, 2018·International Journal of Molecular Sciences·Żaneta Kimber-TrojnarBożena Leszczyńska-Gorzelak
Jul 11, 2013·Journal of Pediatric Gastroenterology and Nutrition·Maricela Diaz-SotomayorBuford L Nichols
Aug 12, 2014·Current Opinion in Clinical Nutrition and Metabolic Care·Jonathan Pinkney
Aug 27, 2019·Frontiers in Endocrinology·Chellakkan S BlessonChandra Yallampalli
Nov 9, 2018·Frontiers in Endocrinology·Xin-Tong FanJing Dong
May 1, 2021·International Journal of Molecular Sciences·Geetali PradhanYuxiang Sun
Jul 14, 2021·The Journal of Clinical Endocrinology and Metabolism·Juan M Jiménez-VacasRaúl M Luque

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