Effect of ghrelin on the biochemical and histopathology parameters and spermatogenesis cycle following experimental varicocele in rat

Andrologia
Nematollah AsadiForouzan Hadipour Moradi

Abstract

Varicocele is one of the major causes of infertility in men in which testicular function is progressively damaged. This study aimed to determine the effect of ghrelin on antioxidant enzymes activity (catalase, SOD, GPx), malondialdehyde (MDA) level and spermatogenesis cycle after induction of varicocele in rat. Twenty-one male Wistar rats were randomly divided into three groups: I-control group, II-rats with induced varicocele and injection of physiological saline and III-rats with induced varicocele and injection of ghrelin. At the end of the experiment, animals were sacrificed and their testes were removed. Antioxidant enzymes activity and MDA level were measured. Histopathological tests, Johnsen's score and sperm parameters were also evaluated. In varicocele group with ghrelin administration (group III), the levels of SOD (0.183 ± 0.024), GPX (9.4250 ± 0.103) and TAC (2.79 ± 0.464) increased significantly (p < 0.05), while MDA (0.304 ± 0.004) level decreased significantly (p < 0.05) compared with varicocele and normal saline group (II). There was no significant difference in the activity of catalase between group III (0.122 ± 0.018) and group II (0.108 ± 0.018), although ghrelin improved catalase activity in group III compar...Continue Reading

References

Jan 1, 1989·Free Radical Biology & Medicine·H Esterbauer, H Zollner
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·L M CarlssonS L Marklund
Jan 1, 1995·Reproduction, Fertility, and Development·R J Aitken
Oct 27, 2001·Diabetes·A M WrenS R Bloom
Sep 5, 2002·Free Radical Biology & Medicine·Roger Harrison
Jan 9, 2003·The Urologic Clinics of North America·Peter C Fretz, Jay I Sandlow
Sep 13, 2003·BJU International·D A Diamond
Mar 26, 2005·Endocrinology·R Fernández-FernándezM Tena-Sempere
Apr 15, 2006·The Journal of Endocrinology·T YadaK Kangawa
Jun 23, 2006·Reproductive Biomedicine Online·Ashok AgarwalShyam S S R Allamaneni
Sep 9, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lixin WangYvette Taché
Nov 8, 2007·American Journal of Physiology. Endocrinology and Metabolism·Miriam GranadoM Angeles Villanúa
Nov 6, 2008·Reproductive Biomedicine Online·Fanuel Lampiao, Stefan S du Plessis
Jan 27, 2009·Urology·Ashok AgarwalEdmund Sabanegh
Oct 2, 2009·Oxidative Medicine and Cellular Longevity·R John Aitken, Shaun D Roman
Feb 23, 2010·Regulatory Peptides·Arash KheradmandMahdi Birjandi
Aug 10, 2010·Accounts of Chemical Research·Krishna P Bhabak, Govindasamy Mugesh
Aug 21, 2010·The Journal of Sexual Medicine·Wael ZohdyMohamad Arafa
Aug 28, 2010·International Journal of Peptides·Manfredi TesauroCarmine Cardillo
Dec 21, 2010·Regulatory Peptides·Arash KheradmandMohammad Javad Tarrahi
Mar 11, 2011·Biology of Reproduction·Haixin Chang, Susan S Suarez
Mar 1, 2012·Biochemical and Biophysical Research Communications·Arash KheradmandBahram Rasoulian
Jul 1, 2004·Indian Journal of Clinical Biochemistry : IJCB·M S RukminiVivian D'Souza
Mar 19, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Fang-Fei LiuYuan Lin
May 30, 2014·The World Journal of Men's Health·Ashok AgarwalStefan S du Plessis
Sep 3, 2014·Irish Journal of Medical Science·B HabibiH R Sadeghipour
Jan 13, 2015·Oxidative Medicine and Cellular Longevity·Carmelo Romeo, Giuseppe Santoro
Jan 17, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Lihong ZhangWei Wang

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Citations

Nov 21, 2019·Asian Journal of Andrology·Ying LiHui-Ping Zhang
Oct 28, 2019·Journal of Assisted Reproduction and Genetics·Yueying WangXiaoran Liu
Nov 5, 2020·Andrology·Mazdak RaziMohammad-Hossein Nasr-Eshafani
Feb 3, 2021·International Journal of Molecular Sciences·Pietro AntonuccioLetteria Minutoli
Nov 11, 2021·Andrologia·Mohamad Reza SadraeiMohammad Hossein Nasr-Esfahani
Dec 31, 2021·American Journal of Reproductive Immunology : AJRI·Forough MahdavinezhadFardin Amidi

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