Effect of Ginkgo biloba extract EGb 761 on the nonspecific and humoral immune responses in a hypothalamic-pituitary-adrenal axis activation model

International Immunopharmacology
María Martha Villaseñor-GarcíaAna Maria Puebla-Pérez

Abstract

We evaluated the immune response of healthy control and stressed Wistar rats submitted to hypothalamic-pituitary-adrenal (HPA) axis activation. Rats were treated with Ginkgo biloba extract (EGb 761) orally (100 mg/kg per day for 7 days). EGb 761 stimulated the digestion index of peritoneal and alveolar macrophages (PM and AM) of stressed rats. Likewise, the cellular immune response measured using the delayed-type hypersensitivity response to sheep red blood cells (SRBC) and the humoral immune response (measured through an anti-SRBC response), were also restored in stressed rats. Thus, this G. biloba extract possesses immunostimulatory activity in addition to its broad spectrum of pharmacological effects.

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Jul 15, 2004·International Immunopharmacology·María Martha Villaseñor-GarcíaAna María Puebla-Pérez
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Citations

Dec 17, 2011·International Immunopharmacology·Muzammal HussainMuti Ur Rehman
Feb 16, 2005·International Immunopharmacology·Bi-Fong LinJin-Yuarn Lin
Aug 20, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jin-Yuarn LinHow-Lan Liou
Mar 26, 2015·Human Vaccines & Immunotherapeutics·Yinghan ChenFengping Shan
Jul 15, 2004·International Immunopharmacology·María Martha Villaseñor-GarcíaAna María Puebla-Pérez

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