Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects

Current Medical Research and Opinion
Sarah M RobertsonScott R Penzak

Abstract

Animal and in vitro data suggest that Ginkgo biloba extract (GBE) may modulate CYP3A4 activity. As such, GBE may alter the exposure of HIV protease inhibitors metabolized by CYP3A4. It is also possible that GBE could alter protease inhibitor pharmacokinetics (PK) secondary to modulation of P-glycoprotein (P-gp). The primary objective of the study was to evaluate the effect of GBE on the exposure of lopinavir in healthy volunteers administered lopinavir/ritonavir. Secondary objectives were to compare ritonavir exposure pre- and post-GBE, and assess the effect of GBE on single doses of probe drugs midazolam and fexofenadine. This open-label study evaluated the effect of 2 weeks of standardized GBE administration on the steady-state exposure of lopinavir and ritonavir in 14 healthy volunteers administered lopinavir/ritonavir to steady-state. In addition, single oral doses of probe drugs midazolam and fexofenadine were administered prior to and after 4 weeks of GBE (following washout of lopinavir/ritonavir) to assess the influence of GBE on CYP3A and P-gp activity, respectively. Lopinavir, ritonavir and fexofenadine exposures were not significantly affected by GBE administration. However, GBE decreased midazolam AUC(0-infinity) and...Continue Reading

References

Nov 7, 1992·Lancet·J Kleijnen, P Knipschild
Feb 22, 2000·Lancet·S C PiscitelliJ Falloon
Sep 2, 2000·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·J W BudzinskiJ T Arnason
Dec 12, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephen C PiscitelliJudith Falloon
Sep 18, 2002·Clinical Pharmacology and Therapeutics·Bill J GurleyCatharina Y W Ang
Mar 29, 2003·Drugs·Risto S Cvetkovic, Karen L Goa
Jun 10, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·An-Fu HsiaoUNKNOWN HCSUS Consortium
Apr 29, 2004·European Journal of Clinical Pharmacology·Chin B EapReinhold Kerb
Jul 13, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michael L LimAngela D M Kashuba
Nov 23, 2006·Clinical Pharmacology and Therapeutics·Maylee ChenAnne N Nafziger
Sep 14, 2007·Clinical Pharmacology and Therapeutics·A N Nafziger, J S Bertino

❮ Previous
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Citations

Dec 6, 2011·Archives of Pharmacal Research·Dong Hee NaHye Suk Lee
May 25, 2013·Clinical Pharmacokinetics·Christian UdeMario Wurglics
Jul 3, 2013·Nature Reviews. Gastroenterology & Hepatology·Jennifer J KiserGregory T Everson
Aug 30, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Eugene Y H YeungThomas K H Chang
Jul 18, 2012·Antimicrobial Agents and Chemotherapy·Maren BlonkDavid Burger
Jan 13, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Angelo A Izzo
Aug 22, 2009·Journal of the American Society of Nephrology : JASN·Thomas D NolinJonathan Himmelfarb
Jan 20, 2012·Clinical Pharmacokinetics·Shaojun Shi, Ulrich Klotz
Nov 6, 2012·Expert Review of Clinical Pharmacology·Janne Hukkanen
Dec 22, 2009·Expert Opinion on Drug Safety·Deborah A Kennedy, Dugald Seely
Jul 20, 2013·Drug Metabolism Reviews·Matthias Unger
Jun 24, 2009·Expert Opinion on Drug Metabolism & Toxicology·Steven M Smith, John G Gums
Jan 7, 2014·Expert Opinion on Drug Metabolism & Toxicology·Walter Emil Haefeli, Alexandra Carls
Oct 18, 2016·Journal of Ginseng Research·Dal-Sik KimMin-Gul Kim
Sep 24, 2011·Medicina clínica·José MoltóBonaventura Clotet
Feb 15, 2011·Heart, Lung & Circulation·Lesley A Braun, Marc Cohen
Jun 18, 2010·Enfermedades infecciosas y microbiología clínica·UNKNOWN Panel de Expertos de Gesida, UNKNOWN Plan Nacional sobre el Sida
Aug 22, 2009·British Journal of Clinical Pharmacology·He-Ping LeiHong-Hao Zhou
Jun 8, 2011·Journal of Clinical Pharmacology·Christine Y MalatiScott R Penzak
Aug 28, 2015·European Journal of Drug Metabolism and Pharmacokinetics·Enoche F OgaToshiharu Horie
Mar 3, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Cheng-Xian GuoHong-Hao Zhou
Mar 5, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ling-Ling DaiHong-Hao Zhou
Jan 30, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Hyun-Jong Cho, In-Soo Yoon
Oct 8, 2016·Expert Review of Clinical Pharmacology·Kristina M BrooksParag Kumar
Sep 23, 2016·International Journal of STD & AIDS·Mohamed A JallohAleah Rodriguez
Feb 11, 2012·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Mark NaccaratoKevin Gough
Feb 12, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jasmina TurkanovicRobert W Milne
Apr 29, 2018·Journal of Food and Drug Analysis·Manuela Grimstein, Shiew-Mei Huang
Apr 20, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Daeun YimDong Hyun Kim
Nov 5, 2019·European Journal of Drug Metabolism and Pharmacokinetics·Artitaya ThiengsusukKesara Na-Bangchang
Jun 3, 2018·European Journal of Drug Metabolism and Pharmacokinetics·Lilian W KibathiParag Kumar
Sep 26, 2019·Chemico-biological Interactions·Clarissa Feltrin, Cláudia Maria Oliveira Simões
May 4, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C BordesP Loubet
Oct 29, 2020·Archives of Toxicology·Jukka HakkolaOlavi Pelkonen
Jul 23, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shanoo SuroowanMohamad Fawzi Mahomoodally
May 1, 2021·Critical Reviews in Oncology/hematology·Paul GougisChristian Funck-Brentano

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