Effect of ginsenoside Re on depression- and anxiety-like behaviors and cognition memory deficit induced by repeated immobilization in rats

Journal of Microbiology and Biotechnology
Bombi LeeDae-Hyun Hahm

Abstract

In this study, we assessed the effects of ginsenoside Re (GRe) administration on repeated immobilization stressinduced behavioral alterations using the forced swimming test (FST), the elevated plus maze (EPM), and the active avoidance conditioning test (AAT). Additionally, we examined the effect of GRe on the central adrenergic system by observing changes in neuronal tyrosine hydroxylase (TH) immunoreactivity and brain-derived neurotrophic factor (BDNF) mRNA expression in the rat brain. Male rats received 10, 20, or 50 mg/kg GRe (i.p.) 30 min before daily exposures to repeated immobilization stress (2 h/day) for 10 days. Activation of the hypothalamic-pituitary-adrenal (HPA) axis in response to repeated immobilization was confirmed by measuring serum levels of corticosterone (CORT) and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Repeated immobilization stress increased immobility in the FST and reduced openarm exploration in the EPM test. It also increased the probability of escape failures in the AAT test, indicating a reduced avoidance response. Daily administration of GRe during the repeated immobilization stress period significantly inhibited the stress-induced behavioral deficits in these b...Continue Reading

Citations

Oct 30, 2012·BMC Complementary and Alternative Medicine·Kang-Woo LeeEun Jin Yang
Nov 28, 2015·Journal of Natural Medicines·Bombi LeeDae-Hyun Hahm
Dec 4, 2015·International Journal of Molecular Sciences·Zegang MaQimin Wang
Jan 24, 2017·Phytotherapy Research : PTR·Jin Gyu ChoiMyung Sook Oh
Feb 22, 2018·Neural Plasticity·Enrico SangiovanniFrancesca Calabrese
Nov 15, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Bombi LeeDae-Hyun Hahm
Sep 22, 2018·The International Journal of Neuroscience·Amal Chandra Mondal, Mahino Fatima
Apr 9, 2014·Neuroreport·Peng LiHaifeng Zhai
Apr 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Weijie XieXiaobo Sun
Jun 2, 2018·BioMed Research International·Mengmeng ZhengChunchao Han
Sep 22, 2020·Brain and Neuroscience Advances·Laurel S MorrisJames W Murrough

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The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Bombi LeeDae-Hyun Hahm
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Bombi LeeDae-Hyun Hahm
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