Effect of glucagon on protein synthesis in human rectal cancer in situ

Annals of Surgery
W H HartlF W Schildberg

Abstract

The purpose of this study was to determine the effect of glucagon or placebo on the rate of tumor fractional protein synthesis in situ in patients with localized rectal cancer who were not malnourished, demonstrated normal glucagon concentrations, and could therefore be used as a model to study the glucagon effect. Cancer cachexia is associated with an increased concentration of counterregulatory hormones, including glucagon. This altered hormonal milieu may not only contribute to malnutrition, but also promote tumor growth, because previous experimental work suggests that glucagon can cause human colorectal tumor cells to proliferate. Corresponding mechanisms in vivo have, thus far, not been investigated. Advanced mass spectrometry techniques (capillary gas chromatography [GC]/combustion isotope ratio mass spectrometry [IRMS]) were used to determine directly the incorporation rate of 1-[13C]-leucine into tissue protein. Because GC/IRMS requires only a small sample volume, three consecutive endoscopic biopsies could be obtained from the same tumor to determine isotopic enrichments at baseline, after a 4-hour glucagon infusion (3 ng/kg/min), or after placebo. In patients with localized rectal cancer, glucagon caused the tumor fr...Continue Reading

References

Mar 1, 1976·The Journal of Clinical Investigation·R S SherwinP Felig
Apr 1, 1992·Clinical Science·K G ParkP J Garlick
Jul 1, 1992·The British Journal of Surgery·S D HeysO Eremin
Dec 1, 1991·Current Opinion in Cell Biology·R E Rhoads
Sep 1, 1991·Annals of Clinical Biochemistry·M L KnappR H Phillips
Mar 1, 1990·Baillière's Clinical Gastroenterology·R A Goodlad, N A Wright
Mar 1, 1990·The British Journal of Surgery·R G Douglas, J H Shaw
Sep 1, 1990·The American Journal of Physiology·W H HartlF W Schildberg
May 16, 1988·Biochemical and Biophysical Research Communications·N WatanabeS Tarui
Nov 1, 1986·Archives of Surgery·V D Dembrow
Dec 1, 1985·American Journal of Surgery·M P MoyerK R Sirinek
Dec 1, 1983·Annals of Surgery·M E BurtM F Brennan
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H Murakami, H Masui
Jul 15, 1982·International Journal of Cancer. Journal International Du Cancer·O KoboriF Martin
Jun 15, 1980·Cancer·G P BuzbyE F Rosato
Oct 1, 1995·Current Problems in Surgery·L E Harrison, M F Brennan
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·A ImdahlG S Baldwin
Sep 1, 1993·British Journal of Cancer·M S WilsonP F Schofield
Nov 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S A WatsonR J Steele

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Citations

Jun 23, 1999·Journal of Chromatography. a·W Meier-Augenstein
Feb 24, 2016·Oncogenesis·P E Porporato
Jan 19, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Surajeet K Patra, Sarika Arora
May 25, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Wolfgang H HartlBruce W Patterson
Mar 7, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Peter RittlerWolfgang H Hartl
Jun 18, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·Peter RittlerWolfgang H Hartl
Mar 11, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·W Meier-Augenstein
Apr 17, 2002·BMC Cancer·Gislaine VentrucciMaria Cristina Cintra Gomes-Marcondes
Jan 1, 2020·Clinical Proteomics·Saira SaleemChris Sutton
May 10, 2006·American Journal of Physiology. Endocrinology and Metabolism·Viraine WeerasooriyaSamuel Klein
Apr 6, 2000·American Journal of Physiology. Endocrinology and Metabolism·P RittlerW H Hartl
Nov 19, 2020·International Journal of Molecular Sciences·Elisabeth WyartPaolo E Porporato

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