PMID: 9537284Apr 16, 1998Paper

Effect of glucan on murine lungs

Journal of Toxicology and Environmental Health. Part a
M R SchuylerA Cherne

Abstract

Glucan, a folded high-molecular-weight polysaccharide, has multiple effects in animals when administered intravenously or intraperitoneally, but not when administered by inhalation. The hypotheses tested were whether intratracheal administration of glucan can cause lung damage and whether some of the resulting lung injury is immunologically mediated. There was a dose-response relationship between the amount of intratracheally injected glucan and the extent of pulmonary histologic abnormalities, which consisted of peribronchiolar and intraalveolar infiltration with chronic inflammatory cells. An attempt to adoptively transfer increased susceptibility to glucan induced lung injury was made. Cells cultured with glucan were transferred into naive recipients before intratracheal glucan exposure. The extent of pulmonary inflammation that occurred as a result of intratracheal injection of glucan was not affected by transfer of cultured cells from glucan-treated animals. However, high concentrations of glucan in culture did produce cells with the appearance of lymphoblasts. These data indicate that glucan induces lung injury, but that there is no evidence of cell mediation of pulmonary injury induced by intratracheal exposure to glucan.

Citations

Oct 30, 2007·Journal of Toxicology and Environmental Health. Part a·S P StraszekP S Thorne
Feb 18, 2003·Journal of Toxicology and Environmental Health. Part a·Michael P DeLormeDavid J P Bassett
Jun 15, 2007·Journal of Toxicology and Environmental Health. Part a·Shih-Houng YoungVincent Castranova
Mar 22, 2013·Journal of Toxicology and Environmental Health. Part a·S ViegasC Viegas
Oct 16, 2007·Journal of Toxicology and Environmental Health. Part a·V LiebersTh Brüning

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