PMID: 488525Jul 1, 1979Paper

Effect of glucocorticoid levels in vivo on growth hormone biosynthesis

Molecular and Cellular Endocrinology
W J Brattin, R Portanova

Abstract

The rate of growth hormone (GH) biosynthesis in pituitary cells prepared from rats with different histories of glucocorticoid exposure was analyzed by a dual-labeling acrylamide-gel technique. Glucocorticoid deficiency, produced by adrenalectomy, reduces GH synthesis by approximately 50%. GH synthesis adrenalectomized rats treated with either natural or synthetic glucocorticoids, is restored to normal or above normal levels. Acute exposure (1 h) of cells to corticosterone in vitro does not produce a significant increase in GH synthesis. Adrenalectomized rats treated with steroid for one day show a small but detectable increase in GH synthesis, while treatment for 3--6 days results in progressively larger stimulatory effects. All of these results are similar to previous findings regarding glucocorticoid stimulation of GH synthesis in vitro.

References

Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A DupontC H Li
Feb 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·R PortanovaG Sayers
Jul 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·R Portanova
Sep 23, 1974·Biochemical and Biophysical Research Communications·K N JohanssonC Y Bowers
Jul 10, 1974·Biochemical and Biophysical Research Communications·J S Tsai, H H Samuels
Dec 9, 1968·Biochemical and Biophysical Research Communications·P O KohlerP L Rayford
Apr 1, 1970·The American Journal of the Medical Sciences·J J DellerJ A Linfoot
Nov 1, 1965·The Journal of Clinical Endocrinology and Metabolism·A G Frantz, M T Rabkin
Dec 1, 1966·The Journal of Endocrinology·A Pecile, E Müller
Dec 31, 1964·The New England Journal of Medicine·A G FRANTZ, M T RABKIN

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