Effect of glutamate ingestion on whole-body glutamate turnover in healthy elderly and patients with chronic obstructive pulmonary disease

Nutrition
Erica P A RuttenA M Schols

Abstract

Decreased whole-body glutamate turnover is found in healthy elderly and in patients with chronic obstructive pulmonary disease (COPD). Glutamate supplementation as an option to increase whole-body glutamate turnover and, hence, glutamate availability has never been investigated. In the present study, we developed a protocol based on repeated glutamate ingestion to increase plasma glutamate concentration to a steady-state level without inducing toxic side effects and to evaluate the effect of repeated glutamate ingestion on whole-body glutamate turnover in patients with COPD and healthy elderly. In part 1, the response of plasma glutamate concentration was determined in young healthy volunteers who repeatedly ingested a glutamate solution. The tolerance of the glutamate drink was evaluated in 26 healthy volunteers by a food tolerance questionnaire. In part 2, eight male patients with COPD and eight healthy elderly ingested the glutamate drink, an isomolar amount of a glutamine drink, or only water to test the effect on plasma glutamate concentration and whole-body glutamate turnover. In part 1, repeated ingestion of 30 mg of glutamate per kilogram of body weight every 20 min increased plasma glutamate concentration five-fold to ...Continue Reading

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Citations

Apr 22, 2010·American Journal of Physiology. Endocrinology and Metabolism·Juan C MariniBrendan Lee
May 12, 2011·American Journal of Physiology. Endocrinology and Metabolism·G C Ligthart-Melis, N E P Deutz
May 5, 2007·American Journal of Respiratory and Critical Care Medicine·Mariève DoucetFrançois Maltais
Sep 6, 2012·International Journal of Molecular Sciences·Akiva LeibowitzAlexander Zlotnik
Apr 25, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Erica P A RuttenAnnemie M W J Schols
Mar 23, 2011·Respiratory Physiology & Neurobiology·Simon MarwoodPeter Calverley
Feb 19, 2008·Physiology & Behavior·Martin R YeomansJohn Prescott
Oct 26, 2018·JPEN. Journal of Parenteral and Enteral Nutrition·Mahmoud A MohammadJuan C Marini
Oct 22, 2014·The American Journal of Clinical Nutrition·Nikki BuijsMechteld A R Vermeulen
Mar 5, 2016·Nutrition Reviews·Dominique Meynial-Denis
Jun 25, 2016·Molecular Carcinogenesis·Ping-Ching HsuPeter G Shields
Mar 12, 2008·Alimentary Pharmacology & Therapeutics·J H C PetersA A van Bodegraven
May 22, 2007·The Journal of Nutrition·Christophe Moinard, Luc Cynober

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