PMID: 16524503Mar 10, 2006Paper

Effect of glutamine depletion on immunity and other organ function in critically ill patients

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Xin-ying WangJie-shou Li

Abstract

To evaluate the effect of glutamine depletion on immunity and other organ function in critically ill patients. Ten healthy individuals served as control group. Forty seriously ill patients [acute pathological and chronic health evaluation II (APACHE II) score> or =8] admitted to the surgical critical care unit (SICU) were enrolled for study. Blood samples were collected at 6:00 am 48 hours after the admission for the determination of plasma glutamine (Gln), and parameters pertaining to immunity and organ functions. The Gln levels in critically ill patients were significantly lower than that of control and negatively correlated with APACHE II score (r=-0.572, P<0.05). The CD4/CD8 ratio was positively correlated with the Gln level (r=0.704, P<0.05), while the monocyte HLA-DR expression lowered as compared to control. In patients with normal glutamine level, the incidence of abnormal total bilirubin >19 micromol/L, serum creatinine >110 micromol/L, and oxygenation index <300 mm Hg (1 mm Hg=0.133 kPa) was lower compared with those with low glutamine level (all P<0.05). In non-survivors Gln was significantly reduced to (333.2+/-95.1) micromol/L and it was significantly lower as compared to that of survivors (466.1+/-125.2) micromol/...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The National Medical Journal of India
Nilanchal Chakraborty, Banani Poddar
Critical Care : the Official Journal of the Critical Care Forum
Jan Wernerman
The New England Journal of Medicine
Nikki BuijsPaul A M van Leeuwen
The New England Journal of Medicine
Bruce R Bistrian
The New England Journal of Medicine
Daren HeylandCanadian Clinical Care Trials Group
© 2021 Meta ULC. All rights reserved